Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.2174/0929867324666170426102343 |
Depleted Uranium and Human Health | |
Faa, Armando1,2; Gerosa, Clara1,2; Fanni, Daniela1,2; Floris, Giuseppe3; Eyken, Peter V.4; Lachowicz, Joanna I.5; Nurchi, Valeria M.5 | |
通讯作者 | Faa, Armando |
来源期刊 | CURRENT MEDICINAL CHEMISTRY |
ISSN | 0929-8673 |
EISSN | 1875-533X |
出版年 | 2018 |
卷号 | 25期号:1页码:49-64 |
英文摘要 | Depleted uranium (DU) is generally considered an emerging pollutant, first extensively introduced into environment in the early nineties in Iraq, during the military operation called "Desert Storm". DU has been hypothesized to represent a hazardous element both for soldiers exposed as well as for the inhabitants of the polluted areas in the war zones. In this review, the possible consequences on human health of DU released in the environment are critically analyzed. In the first part, the chemical properties of DU and the principal civil and military uses are summarized. A concise analysis of the mechanisms underlying absorption, blood transport, tissue distribution and excretion of DU in the human body is the subject of the second part of this article. The following sections deal with pathological condition putatively associated with overexposure to DU. Developmental and birth defects, the Persian Gulf syndrome, and kidney diseases that have been associated to DU are the arguments treated in the third section. Finally, data regarding DU exposure and cancer insurgence will be critically analyzed, including leukemia/lymphoma, lung cancer, uterine cervix cancer, breast cancer, bladder cancer and testicular cancer. The aim of the authors is to give a contribution to the debate on DU and its effects on human health and disease. |
英文关键词 | Depleted uranium uranium chemical properties uranium metabolism uranium toxicity Persian Gulf syndrome desert storm |
类型 | Review |
语种 | 英语 |
国家 | Italy ; Belgium |
收录类别 | SCI-E |
WOS记录号 | WOS:000422944100005 |
WOS关键词 | GULF-WAR VETERANS ; LUNG EPITHELIAL-CELLS ; CR-39 TRACK DETECTOR ; ALL-CAUSE MORTALITY ; IN-VITRO ; BALKAN VETERANS ; CANCER-RISK ; OXIDATIVE STRESS ; ESKAN-DISEASE ; EXPOSURE |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/208532 |
作者单位 | 1.Univ Cagliari, Dipartimento Sci Chirurg, Ist Anat Patol, Cagliari, Italy; 2.AOU Cagliari, Cagliari, Italy; 3.Katholieke Univ Leuven, Dept Pathol, Leuven, Belgium; 4.Genk Gen Hosp, Dept Pathol, Genk, Belgium; 5.Univ Cagliari, Dipartimento Sci Chim & Geol, Cittadella Univ, I-09042 Cagliari, Italy |
推荐引用方式 GB/T 7714 | Faa, Armando,Gerosa, Clara,Fanni, Daniela,et al. Depleted Uranium and Human Health[J],2018,25(1):49-64. |
APA | Faa, Armando.,Gerosa, Clara.,Fanni, Daniela.,Floris, Giuseppe.,Eyken, Peter V..,...&Nurchi, Valeria M..(2018).Depleted Uranium and Human Health.CURRENT MEDICINAL CHEMISTRY,25(1),49-64. |
MLA | Faa, Armando,et al."Depleted Uranium and Human Health".CURRENT MEDICINAL CHEMISTRY 25.1(2018):49-64. |
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