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The Campanian-Lower Paleogene successions exposed at the Kharga Oasis contain well-preserved gastropods. Nineteen gastropod species are identified and described in detail. Two new species are established: Gisortia khargaensis from the lower Eocene El Rufuf Formation and Ornopsis? barisensis from the lower Paleocene Kurkur Formation. In addition to, Turritella (Torquesia) derbesi Coquand is recorded herein for the first time from Egypt. The studied gastropods belonging to four clades: Sorbeoconcha (Metacerithium abictiforme (Wanner), Mesalia hofana Mayer-Eymar, Mesalia sp., Turritella (Torquesia) derbesi Coquand, Turritella (Torquesia) forgemoli Coquand, Turritella kaserensis Hewaidy and Azab, Turritella sp.), Littorinimorpha (Cypraedia bullina Oppenheim, Gisortia khargaensis nov. sp., Natica farafrensis Wanner, Aporrhais schweinfurthi (Quaas), Drepanocheilus bicarinatus Abbass, Drepanocheilus? sp., Anchura? unicarinatus (Abbass), Epitonium sp.), Neogastropoda (Ornopsis? barisensis nov. sp., Rostellana daniensis (Quaas), Vouta sp.), and Heterobranchia (Avellana cretacea Quaas).