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The insufficiency water for irrigation is becoming the most vital problem for corn productivity in semi-arid areas. Thus, the improvement of water-saving farming strategies is important to work out the water deficiency problem that affects maize productivity in semi-arid regions. A field research work was conducted during 2011-12 in a semi-arid area of Pakistan to clarify the interactive effects of soil amendments and irrigation levels on the maize yields, water use efficiency, evapotranspiration and total dry matter accumulations. We tested the following five soil amendments (farm yard manure at 5 t ha(-1); wheat crop residue at 5 t ha(-1); gypsum at 1 t ha(-1); qemyisol at 10 kg ha(-1); humic acid at 20 kg ha-1) with two irrigation levels (350 mm and 175 mm) and traditional planting with no irrigation (CK), respectively. The results clearly indicated that soil amendment such as wheat crop residue at 5 t ha-(1) with irrigation 350 mm could enhance the soil water availability in 0-100 cm during the key growth stages, as well as grain yields significant increased by (62%); water use efficiency (WUE) and rainfall use efficiency (RUE) were improved by (35%) and (50%) as compared with CK1, respectively. As the amount of irrigation increased, the irrigation water use efficiency (IWUE), irrigation water productivity (IWP) decreased but the maize yields and net economic benefit tended to increase. The economic analysis also suggested that higher (45%) of net economic benefits could be obtained by using wheat crop residue at 5 t ha(-1) as soil amendment with irrigation 350 mm as compared with CK1 treatment. Therefore, our research work recommended that wheat crop residue at 5 t ha(-1) with 350 mm irrigation level is a suitable treatment for efficient consumption of local rainfall and increase maize productivity in semi-arid regions because it improves the WUE, RUE and reduces ET levels, thereby enhancing the grain yield, net profit and to reduce the risk of maize productivity in semi-arid regions.