干旱区生态环境知识资源中心(Arid): 加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A

Arid

	加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A
其他题名	Analysis of Nonylphenol, Octylphenol and Bisphenol A in Animal Tissues by Liquid Chromatography-Tandem Mass Spectrometry with Accelerated Solvent Extraction
	邵兵 1; 韩源 1; 李冬梅 2; 赵榕 1; 孟娟 1; 马亚鲁 3
来源期刊	色谱
ISSN	1000-8713
出版年	2005
卷号	23 期号:4 页码:362-365
中文摘要	建立了测定内分泌干扰物质烷基酚、双酚A的液相色谱-电喷雾串联质谱(负离子模式)分析方法,优化了样品前处理方法.以二氯甲烷作提取溶剂,采用加速溶剂萃取法萃取动物组织样品,萃取液用500 mg OASIS氨基固相萃取柱进行浓缩净化.对流动相组分和流动相添加剂对质谱的离子化效率进行了考察,测得3种化合物在高、中、低3个添加水平的回收率为88% ～101% ,相对标准偏差小于15% ;双酚A、壬基酚和辛基酚的方法检出限分别为0.3, 0.05和0.1 mug/kg.对从北京市场上采集的27份动物组织样品进行检测,结果表明壬基酚广泛存在于各种动物源性食品中,检出含量为0.49～55.98 mug/kg,其中鱼肉组织中都检出壬基酚,而且其含量也较高(9.13～55.98 mug/kg).
英文摘要	A comprehensive analytical method based on liquid chromatography-electrospray ionization tandem mass spectrometry with negative ionization mode has been developed for measuring alkylphenols (AP) and bisphenol A (BPA) in animal tissues. Samples of animal tissues were extracted by accelerated solvent extraction with dichloromethane. Sample concen-tration and purification were performed using an OASIS NH2 solid extraction cartridge. The effects of mobile phase and additives on ionization were assessed. The recoveries for the compounds ranged from 88% to 101% and the relative standard deviations were below 15%. The detection limits of the method under multiple-reaction monitoring mode were 0. 3 , 0. 05 and 0. 1 \|xg/kg for BPA, nonylphenol (NP) and octylphenol (OP) , respectively. The contents of NP ranging from 0. 49 to 55. 98 (xg/kg were found in 27 real samples of animal tissues from Bei-jing market. The results indicate that the endocrine disrupting nonylphenol is ubiquitous in food of animal origin. Nonylphenol was found in all fish samples with concentration levels ranging from 9. 13 to 55. 98 [xg/kg.
中文关键词	加速溶剂萃取 ; 液相色谱-电喷雾质谱/质谱 ; 烷基酚 ; 双酚A ; 动物组织
英文关键词	accelerated solvent extraction liquid chromatography-tandem mass spectrometry alkylpheol bisphenol A animal tissues
语种	中文
国家	中国
收录类别	CSCD
WOS类目	CHEMISTRY ANALYTICAL
WOS研究方向	Chemistry
CSCD记录号	CSCD:2002308
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/206501
作者单位	1.北京市疾病预防控制中心, 北京 100013, 中国; 2.北京市东城区疾病预防控制中心, 北京 100012, 中国; 3.天津大学化学系, 天津 300072, 中国
推荐引用方式 GB/T 7714	邵兵,韩源,李冬梅,等. 加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A[J],2005,23(4):362-365.
APA	邵兵,韩源,李冬梅,赵榕,孟娟,&马亚鲁.(2005).加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A.色谱,23(4),362-365.
MLA	邵兵,et al."加速溶剂萃取-液相色谱-质谱/质谱法分析动物组织中的壬基酚、辛基酚和双酚A".色谱 23.4(2005):362-365.