干旱区生态环境知识资源中心(Arid): 子宫颈原位癌的形态发生和生长特性

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	子宫颈原位癌的形态发生和生长特性
其他题名	Morphygenesis and growing feature about carcinoma in situ of cervix
	曹玉文 1; 孙妍 1; 陆天才 1; 张雪宝 1; 潘晓琳 2; 李锋 1; 蒋金芳 1
来源期刊	临床与实验病理学杂志
ISSN	1001-7399
出版年	2005
卷号	21 期号:3 页码:298-302
中文摘要	目的研究子宫颈原位癌的形态发生和生长特性,以便更深刻认识恶性肿瘤的发生、发展规律.方法62例子宫颈原位癌病例的存档蜡块做连续切片,光镜观察,疑有早期浸润的病例作PAS和银染色.随机选择30例,用免疫组化S-P法检测角蛋白10,14,19和Ki-67抗原的表达.结果62例中32例为单纯原位癌,平均年龄39.03岁,比伴有早期浸润的29例原位癌的平均年龄(49.83)低10岁.形态上,原位癌细胞主要有两种类型:基底细胞样和棘细胞样癌细胞.有10例出现角化型大细胞,3例见到角化珠.基底细胞样癌细胞很少发生浸润,而浸润的癌细胞巢反而可见到棘细胞分化和角化现象,出现细胞间桥和角化珠.癌细胞Ki-67指数明显高于正常和不典型增生子宫颈上皮.角蛋白10阳性细胞明显少于正常子宫颈上皮,角蛋白14和19明显多于正常子宫颈上皮,且空间位置明显上移.原位癌细胞可大片炎性坏死脱落,残存的癌细胞可增生修复,但并不突破基膜向下浸润或向表面不断增生形成肉眼能见到的肿块,而是仍然维持原位癌的状态.结论原位癌细胞增生活跃,分化异常,终末分化受抑,但在相当长时期内处于相对稳定的状态,即使当大片癌细胞脱落,增生修复时仍然维持原位癌的状态.这可能与有的原位癌病例,其癌细胞与相邻正常细胞间仍能维持正常的细胞间通讯以及神经生长因子及其受体对原位癌细胞增殖的调控有一定关系.原位癌细胞出现棘细胞样分化表型时其浸润能力增强,PI增高,这可能与原位癌细胞的来源有一定关系.
英文摘要	Purpose To study the morphygenesis and growing feature about carcinoma in situ of cervix for profoundly understanding the development of malignant tumors. Method 62 cases of a series paraffin sections of carcinoma in .situ of cervix were observed by light microscope with PAS staining and silver staining for some of suspected early infiltration. 30 cases among the 60 cases wore chosen to detect the expression of cytokeratin 10,14,19 and Ki-67 protein by immunohistochemieal technique at random. Result The average age (39. 03 years old) of 32 cases of simple carcinoma in situ was 10 years younger than those 29 patients with early infillration whose average age is 49. 83 years old. The cells of carcinoma in situ have two major morphologic type; cancer cell similar to basal cell of squamous epithelium and cancer cell similar to prickle cells. There were large keratinocyts within the focus of carcinoma in situ in 10 oases with keratin pearls in 3 cases. Cancer cell similar to basal cell seldom showed infiltration. On the contrary, the cancer cells won; more strong infiltrating potential when the cancer had differentiation of prickle-like cell, Ki-67 PI of carcinoma in situ was significantly higher than that in normal and atypical hyperplasia cervical epithelia. Tlie numbers of positive cells of cytokeratin 10 were less than that in normal cervical epithelia. On the other hand, the numbers of positive cells of cytokeratin 14 and 19 were obviously increased in carci-noma in situ with the positive cells moving upwards from the basal layer. After shedding of a large number of cancer cells with inflam-matory necrosis,proliferation of residue cancer cells just recovered the focus of carcinoma in situ without invasion. Conclusions Cer-vical carcinoma in situ showed the characteristics of high PI and abnormal differentiation and restraint of lerminal differentiation but may be persistently maintain in a relatively stable state and the proliferating potentiality of cancer cells was limited in some degree in a peri-od of considerable length. The reasons may be that there are normal intercellular communication between tumorigenic and adjacent nor-mal cells and modulating function of never growth factor and its receptor on cancer cell growth. When cells of carcinoma in situ emerged differentiation similar to prickle cell,the cancer cell showed more strong infiltrating ability and higher PI,it may be associated with ori-gin of cancer cells.
中文关键词	子宫颈肿瘤 ; 癌 ; 原位 ; 分化
英文关键词	cervix neoplasms carcinoma in situ differentiation
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ONCOLOGY
WOS研究方向	Oncology
CSCD记录号	CSCD:1967585
来源机构	石河子大学
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/206444
作者单位	1.石河子大学,实验室、医学院病理学教研室, 新疆地方病与民族高发病省部共建教育重点, 石河子, 新疆 832002, 中国; 2.石河子大学,实验室、医学院病理学教研室,石河子, 新疆地方病与民族高发病省部共建教育重点, 832002
推荐引用方式 GB/T 7714	曹玉文,孙妍,陆天才,等. 子宫颈原位癌的形态发生和生长特性[J]. 石河子大学,2005,21(3):298-302.
APA	曹玉文.,孙妍.,陆天才.,张雪宝.,潘晓琳.,...&蒋金芳.(2005).子宫颈原位癌的形态发生和生长特性.临床与实验病理学杂志,21(3),298-302.
MLA	曹玉文,et al."子宫颈原位癌的形态发生和生长特性".临床与实验病理学杂志 21.3(2005):298-302.