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| 大剂量免疫化疗预防肾癌复发和转移的临床研究 | |
| 其他题名 | Clinical study on the preventive effect of high-dose immuno-chemotherapy on the recurrence and metastasis of renal cell carcinoma |
| 邱建宏 | |
| 来源期刊 | 中华泌尿外科杂志
 |
| ISSN | 1000-6702 |
| 出版年 | 2004 |
| 卷号 | 25期号:5页码:303-305 |
| 中文摘要 | 目的观察免疫化疗对肾癌远期复发及转移的预防作用.方法肾癌根治术后患者18例.男13例,女5例.年龄37～78岁,平均56岁.分2组:①免疫化疗组13例.T1 1例,T2 8例,T3 4例.根治术后第10天起联合应用大剂量白细胞介素-2(远策欣?k,重组人白细胞介素-2,IL-2)和干扰素(远策素?k,重组人干扰素alpha2b,IFN-alpha)皮下注射以及5-氟脲嘧啶(5-Fu)静滴治疗.②对照组5例.T1 1例,T2 3例,T3 1例.均因为经济原因未行免疫化疗,仅行肾癌根治术.免疫治疗方法:IL-2 800万U/次,皮下注射,每周3次,第1、4周; 400万U/次,皮下注射,每周3次,第2、3周;IFN-alpha 600万U/次,皮下注射,每周3次,第2、3、6、7周;900万U/次,皮下注射,每周3次,第5、8周;用药后1h直肠应用消炎痛栓50 mg.5-Fu 1000～1250 mg加入5%葡萄糖液500 ml缓慢静滴(4～6 h),每周1次,第5～8周.2个月为1个治疗周期,间隔3个月可重复进行.治疗后每月检查血常规、肝肾功能、腹部B超、胸部及骨X线. 结果治疗组13例完成1～4个治疗周期,平均1.9个周期.未见严重毒副反应发生.随访60～87个月,12例无癌生存,1例术后43个月出现股骨转移, 现行放疗,病灶稳定.对照组5例术后3～14个月发现远处转移,首发转移病灶:肺3例,肝1例,皮下1例.5例术后生存6～21个月,平均12.8个月.结论以大剂量IL-2为主的免疫化疗方法安全,可有效地预防肾癌的远期复发和转移. |
| 英文摘要 | Objective To study the preventive effect of high-dose immuno-chemotherapy on the re-currence and metastasis of renal cell carcinoma( RCC). Methods Overall 18 patients with RCC(13 men and 5 women;mean age,56 years , range, 37 to 78 years) underwent radical nephrectomy. These cases were assigned to 2 groups. (Dlmmuno-chemotherapy group included 13 cases ( 10 men and 3 women) ,whose tumor stages were T, (1 case) , T2 ( 8 ) and T3 (4 ) . They were treated with high-dose subcutaneous interleukin-2 (IL-2) in combination with interferon-ot(IFN-a) and venous infusion 5-fluorouracil(5-Fu) 10 days after opera-tion. ?Control group included 5 oases (3 men and 2 women) ,whose tumor stages were T, ( 1 case) ,T2(3) , T3(l).They didn’t receive immuno-chemotherapy. The immuno-ehemotherapeutic courses consisted of IL-2 (8 xlO6 U,3 timea/w,weeks 1 and 4;4 x 106 U,3 times/w,weeks 2 and 3) jIFN-a 6 x 10s U,3 times/w, weeks 2,3,6 and7;9xlO6 U,3 times/w, weeks 5 and 8 ) ; and 5-Fu (1000 to 1250 mg, once a week, weeks 5 to 8) . Such therapeutic cycle could be repeated at 3-month intervals. Follow-up was conducted with hemo-gram, hepatic and renal function, ultrasonography of liver and kidney, chest X-ray every month after treat-ment. Long-term outcomes for these patients were analyzed. Results Follow-up of 60 to 87 months was carried out after 1 to 4 therapeutic cycles( mean, 1. 9 cycles) in the 13 cases of immuno-chemotherapy. Of them, 12 cases experienced cancer-free survival. Only 1 case had metastasis in thigh bone 43 months after op-eration. No severe side effects occurred. 5 cases in control group were found with metastasis in 3 to 14 months after operation. The mean survival of control group was 12. 8 months ( range ,6 to 21 months). Conclusions Immuno-cheraotherapy with high-dose subcutaneous IL-2 in combination with IFN-a and venous infusion of S-Fu is safe and effective in prevention of the recurrence and metastasis of RCC. |
| 中文关键词 | 肾肿瘤 ; 癌 ; 免疫化疗 ; 预防 ; 复发 |
| 英文关键词 | Kidney neoplasms Carcinoma Immuno-chemotherapy Prevention Recur-rence |
| 语种 | 中文 |
| 国家 | 中国 |
| 收录类别 | CSCD |
| WOS类目 | SURGERY |
| WOS研究方向 | Surgery |
| CSCD记录号 | CSCD:1585608 |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/205831 |
| 作者单位 | 白求恩国际和平医院泌尿外科, 石家庄, 河北 050082, 中国 |
| 推荐引用方式 GB/T 7714 | 邱建宏. 大剂量免疫化疗预防肾癌复发和转移的临床研究[J],2004,25(5):303-305. |
| APA | 邱建宏.(2004).大剂量免疫化疗预防肾癌复发和转移的临床研究.中华泌尿外科杂志,25(5),303-305. |
| MLA | 邱建宏."大剂量免疫化疗预防肾癌复发和转移的临床研究".中华泌尿外科杂志 25.5(2004):303-305. |
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