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	吗啡对急性心肌梗死保护效应的临床研究
其他题名	Clinical study of protective effect of intravenous morphine on the patients with acute myocardial infarction
	张正义; 李培杰; 陈天铎; 杨兰; 赵建洪; 纳涛; 汤晓琴
来源期刊	中国急救医学
ISSN	1002-1949
出版年	2004
卷号	24 期号:3 页码:160-162
中文摘要	目的研究急性心肌梗死(AMI)患者血浆中降钙素基因相关肽(CGRP)和内皮素-1(ET-1)浓度的变化,以明确吗啡对急性心肌损伤的保护作用.方法30例AMI患者随机分为吗啡组(A组)15例和未用吗啡组(B组)15例,10例健康体检者为正常对照组(C组).A组入院即刻采静脉血2 mL后,立即静脉注射吗啡3 mg,10 min后再次采静脉血2 mL;B组于入院时及10 min后分别采静脉血2 mL,两次采血期间未用吗啡.采用放射免疫法测定血浆CGRP和ET-1浓度.结果A组与B组在入院即刻和10min后的血浆CGRP和ET-1浓度均显著高于C组(P＜0.01);A组与B组在入院即刻的血浆CGRP和ET-1浓度无显著性差异(P＞0.05).但10min后,A组血浆CGRP浓度不仅显著高于B组(P＜0.01),且与入院即刻比较也显著增高(P＜0.01);与之相反,A组血浆ET-1浓度不仅显著低于B组(P＜0.01),且与入院即刻比较也显著降低(P＜0.01).结论静脉注射吗啡能增加AMI患者血浆CGRP浓度,降低ET-1浓度,从而发挥心肌保护效应.
英文摘要	Objective To investigate the effects of morphine on myocardial preservation by the study of concentration of plasma CGRP and ET- 1 in patients with ocule myocardial infarction(AMI) . Methods 30 oases of AMI were divided into two groups at random .Moiphine group(group A) included 15 patients who received intravenous 3 mg of moiphine immediately alter getting 2 mL venous blood sample, and underwent the second blood collection 10 minutes later. 15 patients were in non - morphine, group (group B) who just underwent blood collection after hospitalization immediately and 10 minutes later. 10 healthy cases were selected in the normal control (group C) who underwent 2 mL blood collection. Plasma CGRP and ET- 1 were determined by radioimniunoassny(RIA). Results All AMI patients, plasma CGRP and ET-1 concentration were significantly increased in group A,B than group C( P < 0.01)at baseline and 10 min later. There was no significant difference in plasma ET-1 and CGRP concentration between group A and B( P > 0.05). However , plasma CGRP concentration in group A was not only significantly increased than group B, but also increased significantly than after hospitalization immediately in group A( P < 0.01) .On the contrary, plasma ET- 1 concentration at 10 minutes was decreased significantly than that at baseline in group A( P <0.0l), plasma ET - 1 concentration at 10 minutes was decreased significandy than that in group B( P <0.01). Conclusion Intravenous moiphine had protective effects on AMI by increaaing plasma CGRP concentration and decreasing plasma ET-1 concentration.
中文关键词	吗啡 ; 急性心肌梗死 ; 降钙素基因相关肽 ; 内皮素-1
英文关键词	Morphine Acute myocardial infarction( AMI) Calcitonin gene- related peptide( CGRP) Endothelin - 1 (EF - 1)
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:1606332
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/205703
作者单位	兰州医学院第二附属医院急救中心, 兰州, 甘肃 730030, 中国
推荐引用方式 GB/T 7714	张正义,李培杰,陈天铎,等. 吗啡对急性心肌梗死保护效应的临床研究[J],2004,24(3):160-162.
APA	张正义.,李培杰.,陈天铎.,杨兰.,赵建洪.,...&汤晓琴.(2004).吗啡对急性心肌梗死保护效应的临床研究.中国急救医学,24(3),160-162.
MLA	张正义,et al."吗啡对急性心肌梗死保护效应的临床研究".中国急救医学 24.3(2004):160-162.