干旱区生态环境知识资源中心(Arid): 消化道间叶源性肿瘤49例临床病理和免疫组化研究

Arid

	消化道间叶源性肿瘤49例临床病理和免疫组化研究
其他题名	Gastrointestinal mesenchymal tumors: clinicopathologic and immunohistochemical studies of 49 cases
	郁敏 1; 侯英勇 2; 王坚 3; 朱雄增 3
来源期刊	诊断病理学杂志
ISSN	1007-8096
出版年	2004
卷号	11 期号:4 页码:214-217
中文摘要	目的探讨消化道间叶源性肿瘤的临床病理学特点和免疫组化表型.方法对49例消化道间叶源性肿瘤进行临床病理分析,并行CD117、CD34、actin、desmin、S-100和ALKl等标记和分类,研究GIMT的鉴别诊断.结果49例消化道间叶源性肿瘤中,有36例胃肠道间质瘤,主要由梭形细胞组成,部分病例可呈上皮样,瘤细胞排列呈多样化,主要表达CD117和CD34;4例平滑肌瘤,由嗜伊红梭形细胞组成,瘤细胞弥漫强阳性表达alpha-SMA、MSA和/或desmin;2例神经鞘瘤,形态上与发生于周围软组织的神经鞘瘤有所不同,瘤细胞表达S-100、PGP9.5和GFAP等抗体;炎性纤维性息肉、小肠纤维瘤病和炎性肌纤维母细胞瘤各1例,均表达vimentin,灶性表达actin和desmin,1例炎性肌纤维母细胞瘤尚表达ALK1;余4例难以分类.结论消化道间叶源性肿瘤中以胃肠道间质瘤最为多见,而真正的平滑肌(肉)瘤及神经源性肿瘤均非常少见.采用联合标记物在GIMT的诊断及鉴别诊断中具有重要价值.
英文摘要	Objective To study the clinical, pathological and immunohistochemical characteristics of gastrointestinal mesenchy-mal tumors (GIMTs). Methods The clinical and pathological features of 49 cases of GIMT were reviewed, and immunohisto-chemical study was performed by using a panel of antibodies, including CD117, CD34, actins, desmin, S-100 protein and ALK1. Results Among 49 oases of GIMTs, 36 cases were gastrointestinal stromal tumors. While most GISTs were composed of spindle-shaped cells, some cases showed a predominance of epithelioid cells. The arrangement of neoplastic cells varied greatly among cases. They were positive for CD 117 and/or CD34.4 cases were leiomyomas, similar to their peripheral soft tissue or uterus counterparts. They showed a diffuse and strong staining of alpha-SMA, MSA and desmin. 2 cases of schwannomas were identified. Their morphologic features differed from those of peripheral ones. They were positive for S-100 protein, PGP9.5, and GFAP. There was 1 case each of inflammatory fibrous polyp, mesentery fibromatosis and inflammatory myofroblastic tumor (IMT). These 3 cases showed expression of vimentin, focal staining of actins and/or desmin. Additionally, the IMT case expressed anaplastic lymphoma kinase 1 (ALK1), The remaining 4 cases were unclassified. Conclusion GISTs are the most common mesenchymal tumors in gastrointestinal tract. In contrast, bona fide leimyoma, Ieiomyosarcoma or neural tumors are extremely rare. Using a panel of antibodies is helpful in the differentiatial diagnosis of GIMTs.
中文关键词	消化道间叶源性肿瘤 ; 胃肠道间质瘤 ; 免疫组化
英文关键词	Gastronintestinal mesenchymal tumors Gastronintestinal stromal tumors Immunohistochemistry
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ONCOLOGY
WOS研究方向	Oncology
CSCD记录号	CSCD:1653524
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/205649
作者单位	1.上海市崇明中心医院病理科, 上海 202150, 中国; 2.复旦大学附属中山医院病理科, 上海 200032, 中国; 3.复旦大学附属肿瘤医院病理科, 上海 200032, 中国
推荐引用方式 GB/T 7714	郁敏,侯英勇,王坚,等. 消化道间叶源性肿瘤49例临床病理和免疫组化研究[J],2004,11(4):214-217.
APA	郁敏,侯英勇,王坚,&朱雄增.(2004).消化道间叶源性肿瘤49例临床病理和免疫组化研究.诊断病理学杂志,11(4),214-217.
MLA	郁敏,et al."消化道间叶源性肿瘤49例临床病理和免疫组化研究".诊断病理学杂志 11.4(2004):214-217.