干旱区生态环境知识资源中心(Arid): 310例重症肌无力的外科治疗

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	310例重症肌无力的外科治疗
其他题名	310 cases of thymectomy for myasthenia gravis
	王永忠; 甄文俊; 严伟忠; 余宏峰; 孙耀光; 国红
来源期刊	中华外科杂志
ISSN	0529-5815
出版年	2003
卷号	41 期号:8 页码:607-609
中文摘要	目的评价胸腺切除术治疗重症肌无力的围手术期临床特点及疗效。方法回顾性分析310例经胸腺切除术治疗重症肌无力患者的临床特点、手术方式、围手术期处理及疗效。以临床绝对评分及相对评分为治疗前后疗效主要判断标准。结果全组无手术死亡。直接手术并发症8.7%(27/310)。术后病理检查，异位胸腺发生率38.7%(120/310)，胸腺增生达92.9%(288/310)。术后随访3个月以上者287例(随访率为92.6%)，痊愈7.1%(22/310)、基本痊愈11.3%(35/310)、显效40.0%(124/310)、好转27.1%(84/310)、无效7.1%(22/310)，总有效率85.5%(265/310)。其中随诊病例中Ⅰ型、Ⅱa型、Ⅱb型、Ⅲ型、Ⅳ型有效率分别为90.9%(20/22)、97.6%(40/41)、95.3%(162/170)、80.6%(29/36)和77.8%(14/18)。结论全身型及部分眼肌型重症肌无力患者可首选扩大胸腺切除术治疗，疗效良好。
英文摘要	Objective To evaluate the clinical characteristics and long-terra outcome of 310 oases of thymectomy for myasthenia Gravis. Methods The data of 310 patients with thymectomy were analyzed retrospectively to study the patient selection, operative techniques, perioperative management and results for myasthenia Gravis. Absolute and relative scores for clinical evaluation were used as the criteria to determine the therapeutic effects of thymectomy. Results There were no operative death and postoperative complication rates were 8. 7% (27/310). The extra anatomic thymic tissue was found in up to 38. 7% (120/ 310)patients and thymus hyperplasia occurred in 92. 9% (288/310)cases. 92. 6% (287/310) postoperative patients were followed up for 3 or more months; the percentage of patients being remitted, essentially remitted, significantly effective, effective and non-effective were 7.1% (22/310), 11.3% (35/310) 40. 0% (124/310) , 27. 1% (84/310), 7. 1% (22/310) respectively. The total long-term effective rate was 85. 5% (265/310). The effective rate for type I, Ha,lib,I, IV was 90. 9% (20/22) , 97. 6% (40/ 41) , 95. 3% (162/170), 80. 6% (29/36) , 77. 8% (14/18 ) respectively. Conclusions Generalized typed and properly selected recurrent ocular-typed patients with Myasthenia Gravis undergoing extensive thymectomy would have good long-term outcomes.
中文关键词	重症肌无力 ; 胸腺切除术 ; 预后
英文关键词	myasthenia gravis thymectomy prognosis
语种	中文
国家	中国
收录类别	CSCD
WOS类目	SURGERY
WOS研究方向	Surgery
CSCD记录号	CSCD:1261594
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/204733
作者单位	卫生部北京医院心胸外科, 100730
推荐引用方式 GB/T 7714	王永忠,甄文俊,严伟忠,等. 310例重症肌无力的外科治疗[J],2003,41(8):607-609.
APA	王永忠,甄文俊,严伟忠,余宏峰,孙耀光,&国红.(2003).310例重症肌无力的外科治疗.中华外科杂志,41(8),607-609.
MLA	王永忠,et al."310例重症肌无力的外科治疗".中华外科杂志 41.8(2003):607-609.