干旱区生态环境知识资源中心(Arid): 93例亚临床甲状腺功能减退症的随访研究

Arid

	93例亚临床甲状腺功能减退症的随访研究
其他题名	A prospective study of 93 patients with subclinical hypothyroidism
	史晓光; 崇巍; 滕卫平; 单忠艳; 李玉姝; 关海霞; 滕晓春; 佟雅洁; 陈威; 李智; 满娜; 滕笛
来源期刊	中华内分泌代谢杂志
ISSN	1000-6699
出版年	2003
卷号	19 期号:2 页码:86-88
中文摘要	目的研究不同碘摄入量地区亚临床甲状腺功能减退症（甲减）的流行病学特点和影响转归的因素。方法选择盘出、彰武和黄骅3个农村社区（分别为低碘、适碘和高碘地区），在入户调查的基础上行采样调查。测定血清TSH、甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）、尿碘浓度及进行甲状腺B超检查，TSH异常者测定FT_3、FT_4，筛选出118例亚临床甲减患者。盘山和彰武社区于2年后、黄骅社区于1年后进行随访，再次进行以上检查。结果盘山、彰武和黄骅社区亚临床甲减的患病率分别为0.73%、2.90%和5.96%。亚临床甲减的病因33.1%是自身免疫性甲状腺疾病。在随访到的93例亚临床甲减患者中有4例女性进展为临床甲减。结论随着碘摄入量的增加亚临床甲减的患病北增加，但无明显性别差异。随访研究证实女性、甲减腺自身抗体阳性是亚临床甲减患者进展至临床甲减的危险因素，碘摄入量与亚临床甲减的转归无关。
英文摘要	To investigate epidemiological characteristics of subclinical hypothyroidism and factors influencing its outcome in the areas with different iodine intakes. Methods A cross-sectional epidemiological study in 3 rural communities of Panshan (iodine-deficient) , Zhangwu (covered by iodinated salt from 1996) and Huanghua (iodine-excessive) was performed. Physical examination was performed in 3 761 subjects and sera were sampled. The measurements included TSH, thyroid peroxidase antibody (TPOAb) arid thyroglobulin antibody (TGAb) in the sera. Serum FT_3 and FT_4 were determined in the subjects with abnormal TSH. Urinary iodine concentration and thyroid B ultrasound were also examined. Ninety three patients with subclinical hypothyroidism accepted follow-up 1 year (Huanghua) or 2 years later (Panshan and Zhangwu) and above indexes were reexamined. Results The prevalences of subclinical hypothyroidism in Panshan, Zhangwu and Huanghua areas were 0.73% , 2.90% and 5.96% respectively, and 33. 1% patients were with autoimmune thyroid disease. Of the 93 patients, 4 women developed clinical hypothyroidism 1-2 years later. Conclusion Higher prevalence of subclinical hypothyroidism is found in the area with higher iodine supply. Female and positive thyroid autoantibodies are the risk factors for the evolution of subclinical hypothyroidism into clinical hypothyroidism in this study. However, iodine intake is not related to the outcome of subclinical hypothyroidisms.
中文关键词	亚临床甲状腺功能减退症 ; 随访研究 ; 碘
英文关键词	Subclinicl hypothyroidism Follow-up studies Iodine
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:1302775
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/204728
作者单位	中国医科大学附属第一医院内分泌科, 沈阳, 辽宁 110001, 中国
推荐引用方式 GB/T 7714	史晓光,崇巍,滕卫平,等. 93例亚临床甲状腺功能减退症的随访研究[J],2003,19(2):86-88.
APA	史晓光.,崇巍.,滕卫平.,单忠艳.,李玉姝.,...&滕笛.(2003).93例亚临床甲状腺功能减退症的随访研究.中华内分泌代谢杂志,19(2),86-88.
MLA	史晓光,et al."93例亚临床甲状腺功能减退症的随访研究".中华内分泌代谢杂志 19.2(2003):86-88.