干旱区生态环境知识资源中心(Arid): 电针对血管性痴呆模型大鼠海马神经胶质细胞及微血管的影响

Arid

	电针对血管性痴呆模型大鼠海马神经胶质细胞及微血管的影响
其他题名	Effect of Electroacupuncture on Ultrastructure of Hippocampal Neuroglial Cells and Capillaries in Vascular Dementia Rats
	王黎; 赖新生
来源期刊	针刺研究
ISSN	1000-0607
出版年	2003
卷号	28 期号:4 页码:251-254
中文摘要	目的：观察电针对实验性血管性痴呆（VD）大鼠海马神经胶质细胞和毛细血管的影响。方法：实验用4-血管阻断模型，用Morris水迷宫测定大鼠学习记忆能力，并用电镜观察鼠脑海马神经胶质细胞和毛细血管的超微结构变化。结果：模型组海马神经组织超微结构的形态损害明显，胶质细胞变性、水肿，毛细血管内皮细胞受损。电针能明显减轻或抑制缺血的大鼠海马神经胶质细胞及毛细血管的损害。结论：电针明显改善痴呆大鼠的学习记忆能力，与其对脑组织神经元、神经胶质细胞及微血管的全脑保护作用密切相关。
英文摘要	Objective: To observe the effect of electroacupuncture (EA) on neuroglial cells and capillar-ies of hippocampus in vascular dementia (VD) rats. Methods: Rat YD model was established by using four-vessel occlusion (4-VO) method, and the rats were randomized into model group, EA group and sham-operation group, with 5 rats in each group. EA (150 pulses/min, 2.0 mA, 20 min) was deliv-ered to "Baihui"(GV 20) and "Dazhui"(GV 14) once daily, continuously for 10 days. The brain tis-sue was cut into sections for observing ultrastructural changes of neuroglial cells and capillaries in the hippocampus under transmission electron microscope. Results: In model group, the cellular membrane and the nuclear membrane of neuroglial cells in hippocampus were not clear, the chromatin condensed, the perinuclear organelles decreased in number, disintegrated or disappeared, presenting a big blank region. The hippocampal capillaries showed deformed lumen, indistinct basement membrane, swelling of the endothelial cells, and decrease of nerve synapses. While in acupuncture group, the ultrastruc-tural changes of neuroglial cells were much lighter, such as light swelling of the cellular nuclei and membrane and cytolipin with condensation of the nuclear chromatin but without blank zone; and the mitochondria were close to normal. The capillaries .showed distinct arid smooth lumen, basically intact basement membrane with slight swelling at .the periphery part of the membrane, being apparently lighter than those of model group in the .structural injury. Conclusion; EA could markedly suppress ul-tructural lesion of neuroglial cells and capillaries in hippocampus of VI) rats, and lessen the damage tras of cerebral tissue.
中文关键词	电针 ; 海马 ; 血管性痴呆 ; 超微结构变化
英文关键词	vascular dementia electroacupuncture hippocampus ultrastructural changes
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:1244353
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/204556
作者单位	广州中医药大学, 广州, 广东 510407, 中国
推荐引用方式 GB/T 7714	王黎,赖新生. 电针对血管性痴呆模型大鼠海马神经胶质细胞及微血管的影响[J],2003,28(4):251-254.
APA	王黎,&赖新生.(2003).电针对血管性痴呆模型大鼠海马神经胶质细胞及微血管的影响.针刺研究,28(4),251-254.
MLA	王黎,et al."电针对血管性痴呆模型大鼠海马神经胶质细胞及微血管的影响".针刺研究 28.4(2003):251-254.