干旱区生态环境知识资源中心(Arid): 聚乳酸棒对骨折愈合影响的实验研究

Arid

	聚乳酸棒对骨折愈合影响的实验研究
其他题名	Effect of Absorbable Poly-DL-lactide Rods on Experimental Fracture Healing
	丁永利 1; 宋跃明 1; 王军 2
来源期刊	生物医学工程学杂志
ISSN	1001-5515
出版年	2003
卷号	20 期号:4 页码:708-712
中文摘要	研究国产聚-DL-乳酯棒对骨折愈合的影响。建立尺桡骨骨折固定模型。右侧尺桡骨中外1/4双骨折用PDLLA棒髓内固定，对侧用克氏针固定作为对照。动物术后2、4、6、8、12周处死。作组织切片光镜观察以及骨折断端纵剖面的扫描电镜观察。组织学光镜观察示膜内成骨和软骨内成骨现象在崩折愈合过程中同时存在。12周时都忆顺利愈合。但在同时间点，实验组成骨进程要比对照组的慢。电镜观察显示胶原纤维的生成，钙盐的沉积实验组较对照组慢。然而组织学及电镜所见到骨愈合过程中各阶段的细胞形态、钙盐没积过程表现正常。说明成骨过程是正常的。PDLLA材料对骨折愈合过程有一定的延迟作用，临床上应用于血供丰富部位骨折固定。
英文摘要	This study was designed to assess the effect of a home-bred poly-DL-lactide (PDLLA) rods on experimental fracture healing. An operation was performed to create bilateral ulnar and radial fractures of,forearm in 15 rabbits. The right sides were fixed with 2 PDLLA (Mv= 34 * 10~4,1. 6 mm 1. 6 mm30 mm) rods, and the contralateral sides were fixed with.2 Kirschner wires to be used as controls. After operation, casts were used for external fixation, and the joint above and the joint below the fracture were immobilized. The casts were removed at the 6th week after operation. The specimens were remored at specific intervals between 2 and 12 weeks, Histo-logicaUy, the light microscopy and scanning electron microscopy evaluation of the rabbit ulnar and radial fractures fixation revealed that, the fractured bone gradually healed and the PDLLA rods properly fixed on the fracture area during the implanted period. However, results suggest that internal fixation by absorbable material made the. course of fracture healing slower than that in the control group, but the osteogenesis appeared to be normal. In the absorbable group, the collagenous fiber was characterized by order and orientation, and calcified normally. In conclusion, this kind of PDLLA rods have an effect on delaying the process of the normal union of fracture arid should be applicable to fractures where the tissues are rich in blood supply.
中文关键词	聚-DL-乳酸 ; 内固定 ; 骨折愈合 ; 组织学 ; 超微结构
英文关键词	poly-DL-lactide internal fixation fracture healing histology ultrastructure
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:1267032
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/204315
作者单位	1.四川大学华西医院骨科, 成都, 四川 610041, 中国; 2.绵阳市中心医院骨科, 绵阳, 四川 621000, 中国
推荐引用方式 GB/T 7714	丁永利,宋跃明,王军. 聚乳酸棒对骨折愈合影响的实验研究[J],2003,20(4):708-712.
APA	丁永利,宋跃明,&王军.(2003).聚乳酸棒对骨折愈合影响的实验研究.生物医学工程学杂志,20(4),708-712.
MLA	丁永利,et al."聚乳酸棒对骨折愈合影响的实验研究".生物医学工程学杂志 20.4(2003):708-712.