干旱区生态环境知识资源中心(Arid): 寻常型银屑病患者外周血环氧合酶同工酶的研究

Arid

	寻常型银屑病患者外周血环氧合酶同工酶的研究
其他题名	Expression of Cyclooxygenase mRNA in Peripheral Blood Mononuclear Cells in Patients with Progressive Psoriasis
	贾国泉; 陈志强; 刘训荃
来源期刊	中华皮肤科杂志
ISSN	0412-4030
出版年	2002
卷号	35 期号:4 页码:276-277
中文摘要	目的探讨进行期斑块状银屑病患者外周血单一核细胞（PBMC）中环氧合酶同工酶的表达及其在银屑病发病机制中的作用。方法应用逆转录－聚合酶链反应（RT－PCR）检测了进行期斑块状银屑病患者及健康对照者各30例PBMC中构成性环氧合酶（COX－1）和诱导性环氧合酶（COX－2）mRNA的表达。结果进行期斑块状银屑病患者PBMC中COX－2 mRNA的平均表达水平明显高于健康对照组（P＜0．01），且其mRNA的表达水平与其相应的面积与严重度积分（PASI）呈正相关（P＜0．01）；而两组间COX－1平均表达水平的差异无显著性（P＞0．05）。结论进行期斑块状银屑病患者PBMC中COX－2 mRNA的表达增高，提示可能通过诱导前列腺素（PGs）的产生参与进行期斑块状银屑病的发病。
英文摘要	Objective To investigate the expression levels oleonslitutive cyiilutixygeiui.se (COX - 1) and inducible c:yclooxygenase(COX -2) in progressive plaque psoriasis and their clinical .significance. Methods Re-verse traiiHcripliun-polynierase chain reaction (RT-PCR) technique was applied lo semi-qnanlitalively analyze COX - 1 arid COX -2 mRNA expression in peripheral blood mononuclear cells (PBMC) from 30 psciriatic patients and 30 healthy controls, and the correlation between COX - 1/ -2 and psorialic area and severily index (PASI) was evaluated. Results There was a significant difference of COX -2 mRNA expression level between psorialic pa-tients and normal cunlrola ( P <0. 01), but no such difference was found regarding COX - 1 expression ( P > 0. 05) . A positive correlation was noticed between COX - 2 and PASI ( r = 0. 68, P < 0. 01), but not between COX - I and PASI. Conclusion The increased expression of COX - 2 can stimulate over-production of prostaglandins and may be involved in the pathogenesis of progressive plaque psoriasis.
中文关键词	寻常型银屑病 ; 环氧合酶 ; 同工酶 ; 前列腺素内过氧化物合酶 ; 发病机制 ; 逆转录-聚合酶链反应
英文关键词	psoriasis prostaglandin-endoperoxide synthase
语种	中文
国家	中国
收录类别	CSCD
WOS类目	MEDICINE GENERAL INTERNAL
WOS研究方向	General & Internal Medicine
CSCD记录号	CSCD:1155314
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/203743
作者单位	中国医学科学院、中国协和医科大学皮肤病研究所, 南京, 江苏 210042, 中国
推荐引用方式 GB/T 7714	贾国泉,陈志强,刘训荃. 寻常型银屑病患者外周血环氧合酶同工酶的研究[J],2002,35(4):276-277.
APA	贾国泉,陈志强,&刘训荃.(2002).寻常型银屑病患者外周血环氧合酶同工酶的研究.中华皮肤科杂志,35(4),276-277.
MLA	贾国泉,et al."寻常型银屑病患者外周血环氧合酶同工酶的研究".中华皮肤科杂志 35.4(2002):276-277.