干旱区生态环境知识资源中心(Arid): 卡介苗膀胱灌注前后尿IL-8变化的临床意义

Arid

	卡介苗膀胱灌注前后尿IL-8变化的临床意义
其他题名	Urinary interleukin-8 and pH changes after intravesical bacillus calmette-guerin therapy for superficial bladder cancer: processing and prognostic value
	杨燮樵 1; 龙慧民 1; 李仲宜 1; 严春寅 2
来源期刊	中华泌尿外科杂志
ISSN	1000-6702
出版年	2002
卷号	23 期号:10 页码:607-609
中文摘要	目的探讨浅表性膀胱癌患者术后卡介苗（BCG）灌注治疗前后IL-8及pH值变化与疗效的关系。方法对32例浅表性膀胱癌患者术后应用BCG膀胱灌注治疗，采用免疫化学发光法及常规尿液分析法检测治疗前，治疗1次及6次后IL-8及pH值变化情况。结果 32例患者随访6-25个月，5例肿瘤复发，复发者治疗前IL-8，pH值分别为（181.292.3)ng/L及5.60.8，治疗1次后为（161.364.5)ng/L及6.01.4；未复发组治疗前为（255.682.9)ng/L,6.11.3，治疗1次后为（579.477.8)ng/L,6.20.9，提示I轻工业水平下降与肿瘤复发密切相关（P<0.01)；但同期pH值的差别无显著性意义。结论尿IL-8检测在预测BCG灌注治疗膀胱癌的疗效中有重要意义。
英文摘要	Objective To screen for nonresponding cases of superficial transitional cell carcinoma of the bladder at an early stage of intravesical bacillus Calmette-Guetin( BCG) therapy. Methods IL-8 and urine pH were assayed both before intravesical BCG instillation and after the 1st and 6th instillation for 32 oases of superficial transitional cell bladder caneinoma following TURB or partial cystectomy. Urinary IL-8 was measumed by chemiluminescehce. enzyme immunoraeric assay and urine pH by routine examination. The result was studied with reference to the clinical outcome of the patients. Results All the patients have been followed up for 6～25 months with tumor recurrence in 5. Urinary IL-8 in these 5 dropped to 161. 3 64.5 ng/L after the 1st instillation whereas it was 579.4 77.8 ng/L in the others (P < 0. 01). No signifi-cant change was observed in urine pH. Conclusions Urinary IL-8 provides important data for assessing the therapeutic effect of intravesical BCG instillation on bladder cancer.
中文关键词	膀胱肿瘤 ; 卡介苗 ; 白介素-8 ; 预后
英文关键词	bladder neoplasms bacillus Calmette-Guerin interleukin-8 prognosis
语种	中文
国家	中国
收录类别	CSCD
WOS类目	ONCOLOGY
WOS研究方向	Oncology
CSCD记录号	CSCD:1087223
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/203741
作者单位	1.宁波大学医学院附属李惠利医院泌尿外科, 315040; 2.苏州大学附属第一医院泌尿外科
推荐引用方式 GB/T 7714	杨燮樵,龙慧民,李仲宜,等. 卡介苗膀胱灌注前后尿IL-8变化的临床意义[J],2002,23(10):607-609.
APA	杨燮樵,龙慧民,李仲宜,&严春寅.(2002).卡介苗膀胱灌注前后尿IL-8变化的临床意义.中华泌尿外科杂志,23(10),607-609.
MLA	杨燮樵,et al."卡介苗膀胱灌注前后尿IL-8变化的临床意义".中华泌尿外科杂志 23.10(2002):607-609.