干旱区生态环境知识资源中心(Arid): 早期胚胎组织中滋养细胞可溶性人类白细胞抗原G的表达

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	早期胚胎组织中滋养细胞可溶性人类白细胞抗原G的表达
其他题名	Relationship between trophoblast cell’s human leukocyte antigen G expression and early embryo development
	王琼; 庄广伦; 周灿权; 李洁; 张敏芳; 徐艳文; 舒益民
来源期刊	中华妇产科杂志
ISSN	0529-567X
出版年	2002
卷号	37 期号:12 页码:723-725
中文摘要	目的通过观察可溶性人类白细胞抗原G（sHLA-G)在体外受精-胚胎移植（IVF-ET）后自然流产胚胎组织和绒毛膜癌组织中的表达，以探讨sHLA-G在滋养细胞中的表达及其与胚胎发育的关系。方法应用免疫组织化学标记法，检测14例IVF-ET9IVF-ET组）后自然流产绒毛组织和6例绒毛膜癌（绒毛膜癌组）组织中的sHLA-G表达情况，按染色深浅分为阴性，阳性及强阳性；并与10例正常绒毛（正常绒毛组）组织进行对照。结果（1）IVF-ET组仅1例sHLA-G表达阳性（1/14），其余均为阴性或弱阳性；绒毛膜癌组sHLA-G表达全部强阳性；正常绒毛组sHLA-G表达全部为阳性。（2）3组患者的sHLA-G表达部位主要位于绒毛的细胞滋养细胞。结论 sHLA-G在正常绒毛和绒毛膜癌的滋养细胞中呈高表达，在IVF-ET后自然流产的绒毛组织中表达明显下降，表明sHLA-G在滋养细胞的表达可能与胚胎的早期发育有关。
英文摘要	Objective To study the expression of soluble human leukocyte antigen G (sHLA-G) in trophoblast cells of spontaneous abortion after in vitro fertilization and embryo transfer (IVF-ET) and choriocarcinoma, and explore the relationship between sHLA-G expression in trophoblast cells and the early embryo development Methods 14 cases of trophoblast cells of spontaneous abortion after IVF-ET and 6 cases of choriocarcinoma tissue has been detected, and which were compared with the 10 cases of trophoblast cells of normal villus. Results (l) One case(l/14) has positive sHLA-G expression in IVF-ET group,and other oases in this group are negative or faint sHLA-G expression; ALL cases in choriocarcinoma group are strong positive sHLA-G expression; All cases in mormal villous group are positive sHLA-G expression. (2) sHLA-G is expressed on the cytotrophoblast cells, especially on the extravillus cytotrophablast. The expression level of HLA-G is obviously decreased in the spontaneous abortion group compared with normal group. For single cells, the staining on the choriocarinoma cells are stronger than that of the normal villus cells. Conclusion High expression of sHLA-G in choriocarcinoma trophoblast cells and in frophoblast cells of normal villus and low expression in spontaneous abortion trophoblast cells indicating sHLA-G in trophoblast cells has some relationship with the early embryo development.
中文关键词	早期胚胎组织 ; 滋养细胞 ; 可溶性人类白细胞抗原G
英文关键词	trophoblast HLA antigent histocompatibility antigens class I
语种	中文
国家	中国
收录类别	CSCD
WOS类目	OBSTETRICS GYNECOLOGY
WOS研究方向	Obstetrics & Gynecology
CSCD记录号	CSCD:1080415
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/203732
作者单位	中山大学第一附属医院妇产科, 广州, 广东 510080, 中国
推荐引用方式 GB/T 7714	王琼,庄广伦,周灿权,等. 早期胚胎组织中滋养细胞可溶性人类白细胞抗原G的表达[J],2002,37(12):723-725.
APA	王琼.,庄广伦.,周灿权.,李洁.,张敏芳.,...&舒益民.(2002).早期胚胎组织中滋养细胞可溶性人类白细胞抗原G的表达.中华妇产科杂志,37(12),723-725.
MLA	王琼,et al."早期胚胎组织中滋养细胞可溶性人类白细胞抗原G的表达".中华妇产科杂志 37.12(2002):723-725.