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	笑气吸入用于分娩镇痛的有效性与安全性研究
其他题名	Clinical study on efficacy and safety of labor analgesia with inhalation of nitrous oxide in oxygen
	苏放明; 魏晓萍; 陈小荷; 胡芷洋; 徐宏里
来源期刊	中华妇产科杂志
ISSN	0529-567X
出版年	2002
卷号	37 期号:10 页码:584-587
中文摘要	目的探讨笑气吸入分娩镇痛的有效性与安全性。方法将1300例单胎头位，足月初产妇分为两组。其中，研究组658例。在产程中吸入50笑气与50氧气的混合气体实行分娩镇痛；对照组642例。产程中间断吸入氧气，观察两组产妇疼痛的缓解程度，产程时间，分娩方式，羊水情况，分娩失血量，新生儿出生时的Apgar评分。产妇桡动脉与新生儿脐动脉血气分析的结果。笑气吸入的副反应。结果研究组产妇分娩镇痛的有效率为80.9。总产程时间为468min，活跃期时间为153min，剖宫产率为11.6，羊水污染率22.0，新生儿窒息率1.2，产时出血平均237ml,39.4的产妇出现头晕表现的副反应；而对照组产妇分娩镇痛的有效率为0.9，活跃期时间为187min，剖宫产率为19.3，与研究组比较，差异有显著性（P<0.05)；而产程时间480min，羊水污染率24.3，新生儿窒息率1.7，产时出血平均253ml，与研究组比较，差异无显著性（P>0.05)；对照组产妇无明显的头晕等副反应。两组产妇桡动脉及脐动脉血气分析结果比较，差异无显著性（P>0.05)。对照组产妇无明显的头晕等副反应。两组产妇桡动脉及脐动脉血气分析结果比较，差异无显著性（P>0.05)。结论 50笑气与50氧气的混合气体用于分娩镇痛安全方便，易被产妇接受，可有效地缓解分娩疼痛。增加阴道分娩率，对产程及母儿无不良影响。可作为阴道分娩镇痛的安全有效方法用于临床。
英文摘要	Objective To investigate the efficacy and safety of labor analgesia with inhalation of 50% nitrous oxide in oxygen. Methods A total of 1300 oases of terra primiparous women in labor were divided into two groups. Study group (n = 658) 50% nitrous oxide in oxygen was inhalated during labor for relieving labor pain. Control group (n = 642) intermittent inhalation of 50% oxygen was carried out during labor. Two groups were compared with following indices: duration of the labor, delivery mode, meconium stuined of amniotic fluid, postpartum bleeding volume, neonatal Apgar score, side effect of nitrous oxide, and blood gas analysis of samples from maternal radius artery and fetal umbilical blood. Results The efficiency of relieving labor pain in study group was much better than that of control group (80.9% vs 0.9%, P<0.001). Rate of cesarean section in study group was lower than control group (11.6% vsl9.3%, P<0.05). The active phase of labor in study group was shorter than control group (153 min vs 187 min, P < 0.05). There was side effect of dizziness in 39.4% cases of study group but there were no any complaint in the control group cases. There were no significantly differences in duration of the labor, meconium stained amniotic fluid, postpartum bleeding volume, neonetal Apgar score, and blood gas analysis between two groups (P > 0.05). Conclusion Inhalation of 50% nitrous oxide in oxygen was safe and effective labor analgesia. It is acceptable. The measure of relieving labor pain may increase the vaginal birth rate. There is no sevese side effect on mothen and baby.
中文关键词	笑气吸入 ; 分娩 ; 镇痛 ; 有效性 ; 安全性
英文关键词	labor analgesia, obstetrical nitrous oxide
语种	中文
国家	中国
收录类别	CSCD
WOS类目	OBSTETRICS GYNECOLOGY
WOS研究方向	Obstetrics & Gynecology
CSCD记录号	CSCD:1087593
资源类型	期刊论文
条目标识符	http://119.78.100.177/qdio/handle/2XILL650/203731
作者单位	暨南大学医学院附属第二医院产科, 深圳, 广东 518020, 中国
推荐引用方式 GB/T 7714	苏放明,魏晓萍,陈小荷,等. 笑气吸入用于分娩镇痛的有效性与安全性研究[J],2002,37(10):584-587.
APA	苏放明,魏晓萍,陈小荷,胡芷洋,&徐宏里.(2002).笑气吸入用于分娩镇痛的有效性与安全性研究.中华妇产科杂志,37(10),584-587.
MLA	苏放明,et al."笑气吸入用于分娩镇痛的有效性与安全性研究".中华妇产科杂志 37.10(2002):584-587.