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Tick fauna of rodents was studied in the Muyunkum Desert (Chu-Tallas Interfluve), Eastern Kyzylkum and in the West of Betpakdala. Hyalomma asiaticum asiaticum, Haemaphysalis erinacei turanica and Ornithodoros tartakovskyi ticks were found dominant in all desert regions. However, the degree of dominance of individual species varied in different deserts. Most ticks parasitize Rhombomys opimus and Spermophilus fulvus. Ticks that parasitize rodents are vectors of agents of Crimea-Congo hemorrhagic fever, Q fever, tick-borne spotted fevers, borreliosis.