Arid
DOI10.1016/j.toxicon.2017.05.012
Production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of Rajasthan, India
Tanwar, P. D.1; Ghorui, S. K.2; Kochar, S. K.1; Singh, Raghvendar2; Patil, N. V.2
通讯作者Tanwar, P. D.
来源期刊TOXICON
ISSN0041-0101
出版年2017
卷号134页码:1-5
英文摘要

Snakebite is a significant cause of death and disability in subsistent farming populations of rural India. Antivenom is the most effective treatment of envenoming and is manufactured from IgG of venom immunised horses. Because of complex fiscal reasons, the production, testing and delivery of anti venoms designed to treat envenoming by the most medically-important snakes in the region has been questioned time to time. In this study, we report successful immunisation of dromedaries (Camelus dromedarius) against the venom of Indian saw-scaled Viper-Echis carinatus sochureki. This study assessed the specificity and potential of camels immunised with venom of medically most important snake of Western India, the saw-scaled viper (Echis c. sochureld). Using WHO standard pre-clinical in vivo tests the neutralisation of the venom responsible for the lethal, haemorrhagic, coagulant and local necrotizing activities were measured, since these are the most significant effects that characterize envenoming by this species. The anti-venom was found significantly effective in the neutralisation of all these effects tested and thus, revealed further an immunological perspective, that camel IgG anti-venom (mono specific) would be as efficacious as specific equine anti-venoms or even of better choice in treating snake specific envenoming. (C) 2017 Elsevier Ltd. All rights reserved.


英文关键词Camelid antivenom Echis c. sochureki Lethal dose Preclinical study
类型Article
语种英语
国家India
收录类别SCI-E
WOS记录号WOS:000404699900001
WOS关键词DABOIA-RUSSELII-RUSSELII ; CAPRYLIC-ACID ; SNAKE-VENOM ; CARPET VIPER ; WEST-AFRICA ; ANTIVENOM ; NEUTRALIZATION ; IGG ; EFFICACY ; TRIAL
WOS类目Pharmacology & Pharmacy ; Toxicology
WOS研究方向Pharmacology & Pharmacy ; Toxicology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/202700
作者单位1.SP Med Coll & Hosp, Bikaner 334003, Rajasthan, India;
2.Natl Res Ctr Camel, Bikaner 334003, Rajasthan, India
推荐引用方式
GB/T 7714
Tanwar, P. D.,Ghorui, S. K.,Kochar, S. K.,et al. Production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of Rajasthan, India[J],2017,134:1-5.
APA Tanwar, P. D.,Ghorui, S. K.,Kochar, S. K.,Singh, Raghvendar,&Patil, N. V..(2017).Production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of Rajasthan, India.TOXICON,134,1-5.
MLA Tanwar, P. D.,et al."Production and preclinical assessment of camelid immunoglobulins against Echis sochureki venom from desert of Rajasthan, India".TOXICON 134(2017):1-5.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Tanwar, P. D.]的文章
[Ghorui, S. K.]的文章
[Kochar, S. K.]的文章
百度学术
百度学术中相似的文章
[Tanwar, P. D.]的文章
[Ghorui, S. K.]的文章
[Kochar, S. K.]的文章
必应学术
必应学术中相似的文章
[Tanwar, P. D.]的文章
[Ghorui, S. K.]的文章
[Kochar, S. K.]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。