Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.jsps.2016.10.008 |
Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants | |
El-Meligy, Reham M.1; Awaad, Amani S.2; Soliman, Gamal A.3; Kenawy, Sanaa A.4; Alqasoumi, Saleh I.5 | |
通讯作者 | Awaad, Amani S. |
来源期刊 | SAUDI PHARMACEUTICAL JOURNAL
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ISSN | 1319-0164 |
EISSN | 2213-7475 |
出版年 | 2017 |
卷号 | 25期号:3页码:387-396 |
英文摘要 | The present study aimed to evaluate the anti-ulcerogenic activities and the possible mechanisms of action of seven desert plants from different families. Conyza dioscoridis (L.) Desf. (Asteraceae), Euphorbia hirta L. (Euphorpiaceae), Origanum syriacum L., Salvia lanigera L. (Lamiaceae), Sisymbrium irio L., Solanum nigrum Linn. (Solanaceae) and Solenostemma arghel (Del.) Hayne. (Asclepiadaceae), were tested using prophylactic and curative models of absolute ethanol-induced ulcer, at three doses (125, 250 & 500 mg/kg) of each extract. The investigated extracts possessed dose dependent anti-ulcerogenic activities in both models, with LD50 higher than 5 g/kg. The most effective extracts were C. dioscoridis and S. irio with percent protection of control ulcer; 91.1% and 85.4% respectively. The antisecretory activity of both C. dioscoridis and S. irio appears to be mainly related to the suppression of gastrin release. The in vitro potential radical (DPPH) scavenging activities of the investigated extracts were well supported with the reduction in gastric MDA (50.6% and 43.3%) and enhancing the level of reduced GSH (2.84, 2.59 mg/g tissue) for C. dioscoridis and S. irio respectively. In addition, suppression of the inflammatory mediator TNF-alpha may be one of the possible mechanisms of action. The alcohol extracts of C. dioscoridis and S. irio showed no alteration on liver and kidney functions. Phytochemical screening of the investigated extracts revealed the presence of flavonoids, tannins and sterols which could be related to the activities. (C) 2016 The Authors. Production and hosting by Elsevier B.V. |
英文关键词 | TNF-alpha Conyza dioscoridis Sisymbrium irio Gastrin MDA Reduced GSH |
类型 | Article |
语种 | 英语 |
国家 | Egypt ; Saudi Arabia |
收录类别 | SCI-E |
WOS记录号 | WOS:000397040900012 |
WOS关键词 | GASTRIC-MUCOSAL INJURY ; PLAUNOTOL PREVENTS ; MANGIFERA-INDICA ; RATS ; ETHANOL ; ULCER ; INDOMETHACIN ; EXTRACT ; MODELS ; DAMAGE |
WOS类目 | Pharmacology & Pharmacy |
WOS研究方向 | Pharmacology & Pharmacy |
来源机构 | King Saud University |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/202160 |
作者单位 | 1.Desert Res Ctr, Dept Med & Aromat Plants, Cairo, Egypt; 2.Prince Sattam Bin Abdul Aziz Univ, Dept Pharmacognosy, Fac Pharm, Al Kharj, Saudi Arabia; 3.Al Kharj Univ, Coll Pharm, Dept Pharmacol, Al Kharj, Saudi Arabia; 4.Cairo Univ, Coll Pharm, Dept Pharmacognosy, Giza, Giza Governorat, Egypt; 5.King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia |
推荐引用方式 GB/T 7714 | El-Meligy, Reham M.,Awaad, Amani S.,Soliman, Gamal A.,et al. Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants[J]. King Saud University,2017,25(3):387-396. |
APA | El-Meligy, Reham M.,Awaad, Amani S.,Soliman, Gamal A.,Kenawy, Sanaa A.,&Alqasoumi, Saleh I..(2017).Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants.SAUDI PHARMACEUTICAL JOURNAL,25(3),387-396. |
MLA | El-Meligy, Reham M.,et al."Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants".SAUDI PHARMACEUTICAL JOURNAL 25.3(2017):387-396. |
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