Arid
DOI10.1016/j.jsps.2016.10.008
Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants
El-Meligy, Reham M.1; Awaad, Amani S.2; Soliman, Gamal A.3; Kenawy, Sanaa A.4; Alqasoumi, Saleh I.5
通讯作者Awaad, Amani S.
来源期刊SAUDI PHARMACEUTICAL JOURNAL
ISSN1319-0164
EISSN2213-7475
出版年2017
卷号25期号:3页码:387-396
英文摘要

The present study aimed to evaluate the anti-ulcerogenic activities and the possible mechanisms of action of seven desert plants from different families. Conyza dioscoridis (L.) Desf. (Asteraceae), Euphorbia hirta L. (Euphorpiaceae), Origanum syriacum L., Salvia lanigera L. (Lamiaceae), Sisymbrium irio L., Solanum nigrum Linn. (Solanaceae) and Solenostemma arghel (Del.) Hayne. (Asclepiadaceae), were tested using prophylactic and curative models of absolute ethanol-induced ulcer, at three doses (125, 250 & 500 mg/kg) of each extract.


The investigated extracts possessed dose dependent anti-ulcerogenic activities in both models, with LD50 higher than 5 g/kg. The most effective extracts were C. dioscoridis and S. irio with percent protection of control ulcer; 91.1% and 85.4% respectively. The antisecretory activity of both C. dioscoridis and S. irio appears to be mainly related to the suppression of gastrin release. The in vitro potential radical (DPPH) scavenging activities of the investigated extracts were well supported with the reduction in gastric MDA (50.6% and 43.3%) and enhancing the level of reduced GSH (2.84, 2.59 mg/g tissue) for C. dioscoridis and S. irio respectively. In addition, suppression of the inflammatory mediator TNF-alpha may be one of the possible mechanisms of action. The alcohol extracts of C. dioscoridis and S. irio showed no alteration on liver and kidney functions. Phytochemical screening of the investigated extracts revealed the presence of flavonoids, tannins and sterols which could be related to the activities. (C) 2016 The Authors. Production and hosting by Elsevier B.V.


英文关键词TNF-alpha Conyza dioscoridis Sisymbrium irio Gastrin MDA Reduced GSH
类型Article
语种英语
国家Egypt ; Saudi Arabia
收录类别SCI-E
WOS记录号WOS:000397040900012
WOS关键词GASTRIC-MUCOSAL INJURY ; PLAUNOTOL PREVENTS ; MANGIFERA-INDICA ; RATS ; ETHANOL ; ULCER ; INDOMETHACIN ; EXTRACT ; MODELS ; DAMAGE
WOS类目Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
来源机构King Saud University
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/202160
作者单位1.Desert Res Ctr, Dept Med & Aromat Plants, Cairo, Egypt;
2.Prince Sattam Bin Abdul Aziz Univ, Dept Pharmacognosy, Fac Pharm, Al Kharj, Saudi Arabia;
3.Al Kharj Univ, Coll Pharm, Dept Pharmacol, Al Kharj, Saudi Arabia;
4.Cairo Univ, Coll Pharm, Dept Pharmacognosy, Giza, Giza Governorat, Egypt;
5.King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
推荐引用方式
GB/T 7714
El-Meligy, Reham M.,Awaad, Amani S.,Soliman, Gamal A.,et al. Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants[J]. King Saud University,2017,25(3):387-396.
APA El-Meligy, Reham M.,Awaad, Amani S.,Soliman, Gamal A.,Kenawy, Sanaa A.,&Alqasoumi, Saleh I..(2017).Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants.SAUDI PHARMACEUTICAL JOURNAL,25(3),387-396.
MLA El-Meligy, Reham M.,et al."Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants".SAUDI PHARMACEUTICAL JOURNAL 25.3(2017):387-396.
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