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DOI10.1093/molbev/msx062
Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation
Chen, Bing1; Zhang, Bo1,3; Xu, Lingling1; Li, Qing1; Jiang, Feng2; Yang, Pengcheng2; Xu, Yanan1; Kang, Le1,2
通讯作者Chen, Bing ; Kang, Le
来源期刊MOLECULAR BIOLOGY AND EVOLUTION
ISSN0737-4038
EISSN1537-1719
出版年2017
卷号34期号:5页码:1127-1139
英文摘要

Understanding the roles of transposable elements (TEs) in the evolution of genome and adaptation is a long-sought goal. Here, we present a new model of TE co-option, in which a TE is harnessed by an essential gene and confers local adaptation through heterozygote advantage. We characterized a human Alu-like TE family, the Lm1 elements, in the genome of the migratory locust Locusta migratoria that harbors 0.7 million copies of the elements. Scanning Lm1 insertions in the natural locust populations revealed the widespread high polymorphism of Lm1. An Lm1 was recruited into the coding region of Heat-shock protein 90 (Hsp90), an important molecular chaperone for diverse signal transduction and developmental pathways. Only heterozygotes of the allele are present in natural populations. Allele frequency increases with decreased latitudes in east coastal China, even increasing up to 76% in southern populations. Regions flanking the Lm1 insertion display clear signatures of a selective sweep linked to Lm1. The Lm1-mediated Hsp90 mutation is consequential for the embryonic development of locust. Heterozygous embryos develop faster than the wild type, particularly when cued by long-day parental photoperiod. The heterozygotes also present a reduced within-population variation in embryonic development, i.e., high developmental synchrony of embryos. The naturally occurring Hsp90 mutation could facilitate multivoltinism and developmental synchronization of the locust in southern tropical region. These results revealed a genetic mechanism behind microevolutionary changes in which balancing selection may have acted to maintain the heterozygote advantage through TE co-option in essential genes.


英文关键词balancing selection Hsp90 transposable element selective sweep embryonic development heterozygote advantage
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000399373300008
WOS关键词HEAT-SHOCK PROTEINS ; MOLECULAR CHAPERONE HSP90 ; MIGRATORY LOCUST ; DROSOPHILA-MELANOGASTER ; MORPHOLOGICAL EVOLUTION ; MITOCHONDRIAL GENOMES ; POPULATION-GENETICS ; STRESS-RESPONSE ; CHARGED LINKER ; DESERT LOCUST
WOS类目Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
WOS研究方向Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/201129
作者单位1.Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Rodents, Beijing, Peoples R China;
2.Chinese Acad Sci, Beijing Inst Life Sci, Beijing, Peoples R China;
3.Chinese Acad Agr Sci, Inst Plant Protect, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Chen, Bing,Zhang, Bo,Xu, Lingling,et al. Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation[J],2017,34(5):1127-1139.
APA Chen, Bing.,Zhang, Bo.,Xu, Lingling.,Li, Qing.,Jiang, Feng.,...&Kang, Le.(2017).Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation.MOLECULAR BIOLOGY AND EVOLUTION,34(5),1127-1139.
MLA Chen, Bing,et al."Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation".MOLECULAR BIOLOGY AND EVOLUTION 34.5(2017):1127-1139.
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