Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.micpath.2017.04.014 |
Use of physiological biomarkers in diagnosis along with field trials of different trypanisidal drugs in camels of Cholistan desert | |
Durrani, Aneela Zameer1; Bashir, Zubair1; Mehmood, Khalid2; Avais, Muhammad1; Akbar, Haroon3; Ahmad, Waqas4; Azeem, Muhammad5 | |
通讯作者 | Durrani, Aneela Zameer |
来源期刊 | MICROBIAL PATHOGENESIS |
ISSN | 0882-4010 |
出版年 | 2017 |
卷号 | 108页码:1-5 |
英文摘要 | The point prevalence of trypanosomiasis with different physiological biomarkers along with evaluation of the most responsive trypanosidal drug against trypanosomiasis under field conditions was studied. For this purpose a total of 300 free range camels were selected at different grazing and watering point in Cholistan desert. The study population of camels included 150 clinically suspected camels for trypanosomiasis and 150 healthy camels with normal temperature, pulse and respiration. For therapeutic trials 36 positively diagnosed animals were randomly divided into three experimental groups for therapeutic trials. Group A was treated with Imidocarb dipropionate (ID) @ 1.2 mg kg(-1) body weight; Group B was treated with Diaminazine aceturate (DA) @ 3.5 mg kg(-1) body weight and Group C was treated with Isometamidium chloride hypochloride (IC) @ 0.75 mg kg(-1) body weight of camels. Data on risk factors of age,sex, ectoparasites, housing was also collected. Results revealed an overall 15% point prevalence of trypanosomiasis. There was significant (P < 0.05) decline in the values of physiological biomarkers of total erythrocyte counts, hemoglobin concentration, packed cell volume, serum total proteins and albumin while erythrocyte sedimentation rate was increased in infected camels as compared to healthy ones. Different hepatic enzymes including aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase were also significantly increased in the infected animals. Therapeutic trials indicated that Isometamidium chloride hypochloride (IC) was more effective than Imidocarb dipropionate (ID) and Diaminazine aceturate (DA). It is concluded that haemato-biochemical parameters were important physiological biomarkers and IC was the most responsive therapeutic agent against trypanosomiasis in camels in field conditions. The risk factors analysis showed older camels (>5 years) showed highest infection while infection was found to be lowest in less than 1 year age group. (C) 2017 Elsevier Ltd. All rights reserved. |
英文关键词 | Trypanosoma evansi Camel Cholistan Biomarkers Isometamidium chloride Risk factors Therapeutic trials |
类型 | Article |
语种 | 英语 |
国家 | Pakistan |
收录类别 | SCI-E |
WOS记录号 | WOS:000403032900001 |
WOS关键词 | TRYPANOSOMA-EVANSI ; ISOMETAMIDIUM ; PROFILE ; MILK |
WOS类目 | Immunology ; Microbiology |
WOS研究方向 | Immunology ; Microbiology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/201094 |
作者单位 | 1.Univ Vet & Anim Sci, Dept Clin Med & Surg, Lahore, Pakistan; 2.Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Bahawalpur, Pakistan; 3.Univ Vet & Anim Sci, Dept Parasitol, Lahore, Pakistan; 4.Livestock & Dairy Dev Dept Punjab, Lahore, Pakistan; 5.Univ Vet & Anim Sci, Dept Pathol, Lahore, Pakistan |
推荐引用方式 GB/T 7714 | Durrani, Aneela Zameer,Bashir, Zubair,Mehmood, Khalid,et al. Use of physiological biomarkers in diagnosis along with field trials of different trypanisidal drugs in camels of Cholistan desert[J],2017,108:1-5. |
APA | Durrani, Aneela Zameer.,Bashir, Zubair.,Mehmood, Khalid.,Avais, Muhammad.,Akbar, Haroon.,...&Azeem, Muhammad.(2017).Use of physiological biomarkers in diagnosis along with field trials of different trypanisidal drugs in camels of Cholistan desert.MICROBIAL PATHOGENESIS,108,1-5. |
MLA | Durrani, Aneela Zameer,et al."Use of physiological biomarkers in diagnosis along with field trials of different trypanisidal drugs in camels of Cholistan desert".MICROBIAL PATHOGENESIS 108(2017):1-5. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。