Arid
DOI10.12968/jowc.2017.26.Sup1.S12
Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US
Guest, J. F.1,2,4,5; Weidlich, D.3; Singh, H.3; La Fontaine, J.6; Garrett, A.7; Abularrage, C. J.8,9; Waycaster, C. R.10
通讯作者Guest, J. F.
来源期刊JOURNAL OF WOUND CARE
ISSN0969-0700
EISSN2062-2916
出版年2017
卷号26期号:1页码:S12-S24
英文摘要

Objective: To estimate the cost-effectiveness of using tri-layer porcine small intestine submucosa (SIS; Oasis Ultra) as an adjunct to standard care compared with standard care alone in managing diabetic foot ulcers (DFUs) in the US, from the perspective of Medicare.


Method: A Markov model was constructed to simulate the management of diabetic neuropathic lower extremity ulcers over a period of one year in the US. The model was used to estimate the cost-effectiveness of initially using adjunctive SIS compared with standard care alone to treat a DFU in the US at 2016 prices.


Results: At 12 months after the start of treatment, the use of adjunctive SIS instead of standard care alone is expected to lead to a 42 % increase in the number of ulcer-free months, 32 % increase in the probability of healing, a 3 % decrease in the probability of developing complicated ulcers and a 1 % decrease in the probability of undergoing an amputation. Health-care resource use is expected to be reduced by 11-14 % among patients who are initially managed with adjunctive SIS compared with those initially managed with standard care alone, with the exception of debridement, which is expected to be reduced by 35 %. Hence, the total health-care cost of starting treatment with adjunctive SIS instead of standard care alone was estimated to reduce payer costs by 1% (i. e. $ 105 per patient) over 12 months following the start of treatment.


Conclusion: Within the study’s limitations, the use of adjunctive SIS instead of standard care alone improves outcome for less cost and thereby affords a cost-effective use of Medicare-funded resources in the management of neuropathic foot ulcers among adult patients with type 1 or 2 diabetes mellitus in the US.


英文关键词cost-effectiveness diabetic foot ulcer Oasis Ultra porcine small intestine submucosa tri-layer matrix United States
类型Article
语种英语
国家England ; USA
收录类别SCI-E
WOS记录号WOS:000392426600003
WOS关键词MANAGEMENT
WOS类目Dermatology
WOS研究方向Dermatology
来源机构University of London
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/200902
作者单位1.Catalyst Hlth Econ Consultants, Catalyst, Northwood, Middx, England;
2.Catalyst Hlth Econ Consultants, Hlth Econ, Northwood, Middx, England;
3.Catalyst Hlth Econ Consultants, Northwood, Middx, England;
4.Kings Coll London, Fac Life Sci & Med, Catalyst, London, England;
5.Kings Coll London, Fac Life Sci & Med, Hlth Econ, London, England;
6.Univ Texas Southwestern Med Ctr Dallas, Plast Surg, Dallas, TX 75390 USA;
7.Ben Hogan Bone & Joint Clin, Ft Worth, TX USA;
8.Johns Hopkins Univ Hosp, Diabet Foot & Wound Clin, Surg, Baltimore, MD 21287 USA;
9.Johns Hopkins Univ Hosp, Diabet Foot & Wound Clin, Multidisciplinary Diabet Foot & Wound Clin, Baltimore, MD 21287 USA;
10.Smith & Nephew Biotherapeut, Hlth Econ, Ft Worth, TX USA
推荐引用方式
GB/T 7714
Guest, J. F.,Weidlich, D.,Singh, H.,et al. Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US[J]. University of London,2017,26(1):S12-S24.
APA Guest, J. F..,Weidlich, D..,Singh, H..,La Fontaine, J..,Garrett, A..,...&Waycaster, C. R..(2017).Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US.JOURNAL OF WOUND CARE,26(1),S12-S24.
MLA Guest, J. F.,et al."Cost-effectiveness of using adjunctive porcine small intestine submucosa tri-layer matrix compared with standard care in managing diabetic foot ulcers in the US".JOURNAL OF WOUND CARE 26.1(2017):S12-S24.
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