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DOI | 10.1007/s00415-016-8374-y |
Global and regional annual brain volume loss rates in physiological aging | |
Schippling, Sven1,2; Ostwaldt, Ann-Christin3; Suppa, Per3; Spies, Lothar3; Manogaran, Praveena1,2; Gocke, Carola4; Huppertz, Hans-Juergen5; Opfer, Roland1,2,3 | |
通讯作者 | Schippling, Sven |
来源期刊 | JOURNAL OF NEUROLOGY
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ISSN | 0340-5354 |
EISSN | 1432-1459 |
出版年 | 2017 |
卷号 | 264期号:3页码:520-528 |
英文摘要 | The objective is to estimate average global and regional percentage brain volume loss per year (BVL/year) of the physiologically ageing brain. Two independent, cross-sectional single scanner cohorts of healthy subjects were included. The first cohort (n = 248) was acquired at the Medical Prevention Center (MPCH) in Hamburg, Germany. The second cohort (n = 316) was taken from the Open Access Series of Imaging Studies (OASIS). Brain parenchyma (BP), grey matter (GM), white matter (WM), corpus callosum (CC), and thalamus volumes were calculated. A non-parametric technique was applied to fit the resulting age-volume data. For each age, the BVL/year was derived from the age-volume curves. The resulting BVL/year curves were compared between the two cohorts. For the MPCH cohort, the BVL/year curve of the BP was an increasing function starting from 0.20% at the age of 35 years increasing to 0.52% at 70 years (corresponding values for GM ranged from 0.32 to 0.55%, WM from 0.02 to 0.47%, CC from 0.07 to 0.48%, and thalamus from 0.25 to 0.54%). Mean absolute difference between BVL/year trajectories across the age range of 35-70 years was 0.02% for BP, 0.04% for GM, 0.04% for WM, 0.11% for CC, and 0.02% for the thalamus. Physiological BVL/year rates were remarkably consistent between the two cohorts and independent from the scanner applied. Average BVL/year was clearly age and compartment dependent. These results need to be taken into account when defining cut-off values for pathological annual brain volume loss in disease models, such as multiple sclerosis. |
英文关键词 | Magnetic resonance imaging Brain volumetry Thalamus White matter Grey matter Multiple sclerosis Physiological aging Brain atrophy |
类型 | Article |
语种 | 英语 |
国家 | Switzerland ; Germany |
收录类别 | SCI-E |
WOS记录号 | WOS:000396132000013 |
WOS关键词 | GRAY-MATTER ATROPHY ; REMITTING MULTIPLE-SCLEROSIS ; DEMENTED OLDER-ADULTS ; OPEN ACCESS SERIES ; INTRACRANIAL VOLUME ; LIFE-SPAN ; MRI DATA ; PROGRESSION ; TRAJECTORIES ; DISABILITY |
WOS类目 | Clinical Neurology |
WOS研究方向 | Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/200698 |
作者单位 | 1.Univ Zurich Hosp, Dept Neurol, Neuroimmunol & Multiple Sclerosis Res, CH-8091 Zurich, Switzerland; 2.Univ Zurich, Frauenklinikstr 26, CH-8091 Zurich, Switzerland; 3.Jung Diagnost GmbH, Martinistr 52, D-20251 Hamburg, Germany; 4.Med Prevent Ctr Hamburg, Falkenried 88, D-20251 Hamburg, Germany; 5.Swiss Epilepsy Ctr, Bleulerstr 60, CH-8008 Zurich, Switzerland |
推荐引用方式 GB/T 7714 | Schippling, Sven,Ostwaldt, Ann-Christin,Suppa, Per,et al. Global and regional annual brain volume loss rates in physiological aging[J],2017,264(3):520-528. |
APA | Schippling, Sven.,Ostwaldt, Ann-Christin.,Suppa, Per.,Spies, Lothar.,Manogaran, Praveena.,...&Opfer, Roland.(2017).Global and regional annual brain volume loss rates in physiological aging.JOURNAL OF NEUROLOGY,264(3),520-528. |
MLA | Schippling, Sven,et al."Global and regional annual brain volume loss rates in physiological aging".JOURNAL OF NEUROLOGY 264.3(2017):520-528. |
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