Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1242/jeb.150367 |
Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum | |
Moeller, Karla T.1; Demare, Guillaume2; Davies, Scott1,3; DeNardo, Dale F.1 | |
通讯作者 | Moeller, Karla T. |
来源期刊 | JOURNAL OF EXPERIMENTAL BIOLOGY
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ISSN | 0022-0949 |
EISSN | 1477-9145 |
出版年 | 2017 |
卷号 | 220期号:12页码:2166-2174 |
英文摘要 | The physiological challenges associated with dehydration can induce an increase in plasma glucocorticoid concentrations, a response thought to provide the mechanism for dehydration suppressing immune function. However, a comprehensive examination of the inter-relationship of dehydration, stress and immune function has not been conducted within a single species. We previously demonstrated that Gila monsters (Heloderma suspectum), which inhabit a xeric environment with a predictable seasonal drought, have enhanced measures of innate immunity when dehydrated. These results suggest that, in this species, dehydration may not induce a glucocorticoid response, but, instead, enhances physiological defense mechanisms. To explore this possibility, we examined multiple measures of innate immunity as well as initial and reactive plasma concentrations of glucocorticoids in captive and free-ranging Gila monsters at various hydration states. Our results show that, in this species, dehydration alone does not cause a substantial increase in plasma glucocorticoids, and we provide broader evidence that dehydration enhances defensive mechanisms including stress reactivity and various measures of innate immune function. These findings suggest that physiological responses to dehydration may depend heavily on an organism’s ecology. More research on the effects of dehydration on the glucocorticoid response and immunity will help clarify the interactive roles they play in response to hydration challenges and whether adaptations to water-limited environments influence these interactions. |
英文关键词 | Dehydration Innate immunity Corticosterone Reptile |
类型 | Article |
语种 | 英语 |
国家 | USA ; England |
收录类别 | SCI-E |
WOS记录号 | WOS:000403337600011 |
WOS关键词 | ADULT MALE RATS ; HYDRATION STATE ; WATER RESTRICTION ; INTENSITY EXERCISE ; FLUID BALANCE ; AWASSI-EWES ; BASE-LINE ; STRESS ; RESPONSES ; CORTICOSTERONE |
WOS类目 | Biology |
WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
来源机构 | Arizona State University ; University of Oxford |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/200409 |
作者单位 | 1.Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA; 2.Univ Oxford, Sch Geog & Environm, Oxford OX1 3QY, England; 3.Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA |
推荐引用方式 GB/T 7714 | Moeller, Karla T.,Demare, Guillaume,Davies, Scott,et al. Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum[J]. Arizona State University, University of Oxford,2017,220(12):2166-2174. |
APA | Moeller, Karla T.,Demare, Guillaume,Davies, Scott,&DeNardo, Dale F..(2017).Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum.JOURNAL OF EXPERIMENTAL BIOLOGY,220(12),2166-2174. |
MLA | Moeller, Karla T.,et al."Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum".JOURNAL OF EXPERIMENTAL BIOLOGY 220.12(2017):2166-2174. |
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