Arid
DOI10.1242/jeb.150367
Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum
Moeller, Karla T.1; Demare, Guillaume2; Davies, Scott1,3; DeNardo, Dale F.1
通讯作者Moeller, Karla T.
来源期刊JOURNAL OF EXPERIMENTAL BIOLOGY
ISSN0022-0949
EISSN1477-9145
出版年2017
卷号220期号:12页码:2166-2174
英文摘要

The physiological challenges associated with dehydration can induce an increase in plasma glucocorticoid concentrations, a response thought to provide the mechanism for dehydration suppressing immune function. However, a comprehensive examination of the inter-relationship of dehydration, stress and immune function has not been conducted within a single species. We previously demonstrated that Gila monsters (Heloderma suspectum), which inhabit a xeric environment with a predictable seasonal drought, have enhanced measures of innate immunity when dehydrated. These results suggest that, in this species, dehydration may not induce a glucocorticoid response, but, instead, enhances physiological defense mechanisms. To explore this possibility, we examined multiple measures of innate immunity as well as initial and reactive plasma concentrations of glucocorticoids in captive and free-ranging Gila monsters at various hydration states. Our results show that, in this species, dehydration alone does not cause a substantial increase in plasma glucocorticoids, and we provide broader evidence that dehydration enhances defensive mechanisms including stress reactivity and various measures of innate immune function. These findings suggest that physiological responses to dehydration may depend heavily on an organism’s ecology. More research on the effects of dehydration on the glucocorticoid response and immunity will help clarify the interactive roles they play in response to hydration challenges and whether adaptations to water-limited environments influence these interactions.


英文关键词Dehydration Innate immunity Corticosterone Reptile
类型Article
语种英语
国家USA ; England
收录类别SCI-E
WOS记录号WOS:000403337600011
WOS关键词ADULT MALE RATS ; HYDRATION STATE ; WATER RESTRICTION ; INTENSITY EXERCISE ; FLUID BALANCE ; AWASSI-EWES ; BASE-LINE ; STRESS ; RESPONSES ; CORTICOSTERONE
WOS类目Biology
WOS研究方向Life Sciences & Biomedicine - Other Topics
来源机构Arizona State University ; University of Oxford
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/200409
作者单位1.Arizona State Univ, Sch Life Sci, Tempe, AZ 85287 USA;
2.Univ Oxford, Sch Geog & Environm, Oxford OX1 3QY, England;
3.Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA
推荐引用方式
GB/T 7714
Moeller, Karla T.,Demare, Guillaume,Davies, Scott,et al. Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum[J]. Arizona State University, University of Oxford,2017,220(12):2166-2174.
APA Moeller, Karla T.,Demare, Guillaume,Davies, Scott,&DeNardo, Dale F..(2017).Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum.JOURNAL OF EXPERIMENTAL BIOLOGY,220(12),2166-2174.
MLA Moeller, Karla T.,et al."Dehydration enhances multiple physiological defense mechanisms in a desert lizard, Heloderma suspectum".JOURNAL OF EXPERIMENTAL BIOLOGY 220.12(2017):2166-2174.
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