Knowledge Resource Center for Ecological Environment in Arid Area
| DOI | 10.1038/ja.2016.78 |
| Isolation and anti-HIV-1 integrase activity of Ientzeosides A-F from extremotolerant lentzea sp H45, a strain isolated from a high-altitude Atacama Desert soil | |
| Wichner, Dominik1,2; Idris, Hamidah; Houssen, Wael E.1,4,5; McEwan, Andrew R.1,4; Bull, Alan T.6; Asenjo, Juan A.7; Goodfellow, Michael3; Jasparsi, Marcel1; Ebell, Rainer1; Rateb, Mostafa E.1,8,9 | |
| 通讯作者 | Rateb, Mostafa E. |
| 来源期刊 | JOURNAL OF ANTIBIOTICS
 |
| ISSN | 0021-8820 |
| 出版年 | 2017 |
| 卷号 | 70期号:4页码:448-453 |
| 英文摘要 | The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase. |
| 类型 | Article |
| 语种 | 英语 |
| 国家 | Scotland ; Germany ; England ; Egypt ; USA ; Chile |
| 收录类别 | SCI-E |
| WOS记录号 | WOS:000397547900016 |
| WOS关键词 | HIV-1 INTEGRASE ; SP NOV. ; STREPTOMYCES ; GLYCOSIDES ; CHAXAMYCINS ; GENUS |
| WOS类目 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy |
| 资源类型 | 期刊论文 |
| 条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/200018 |
| 作者单位 | 1.Univ Aberdeen, Marine Biodiscovery Ctr, Dept Chem, Aberdeen, Scotland; 2.Univ Regensburg, Dept Chem, Universitatsstr 31, Regensburg, Germany; 3.Newcastle Univ, Sch Biol, Newcastle Upon Tyne, Tyne & Wear, England; 4.Univ Aberdeen, Inst Med Sci, Aberdeen, Scotland; 5.Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura, Egypt; 6.Univ Kent, Sch Biosci, Kent, OH USA; 7.Univ Chile, Ctr Biotechnol & Bioengn CeBiB, Dept Chem Engn & Biotechnol, Santiago, Chile; 8.Univ West Scotland, Sch Sci & Sport, Paisley PA1 2BE, Renfrew, Scotland; 9.Beni Suef Univ, Sch Pharm, Dept Pharmacognosy, Bani Suwayf, Egypt |
| 推荐引用方式 GB/T 7714 | Wichner, Dominik,Idris, Hamidah,Houssen, Wael E.,et al. Isolation and anti-HIV-1 integrase activity of Ientzeosides A-F from extremotolerant lentzea sp H45, a strain isolated from a high-altitude Atacama Desert soil[J],2017,70(4):448-453. |
| APA | Wichner, Dominik.,Idris, Hamidah.,Houssen, Wael E..,McEwan, Andrew R..,Bull, Alan T..,...&Rateb, Mostafa E..(2017).Isolation and anti-HIV-1 integrase activity of Ientzeosides A-F from extremotolerant lentzea sp H45, a strain isolated from a high-altitude Atacama Desert soil.JOURNAL OF ANTIBIOTICS,70(4),448-453. |
| MLA | Wichner, Dominik,et al."Isolation and anti-HIV-1 integrase activity of Ientzeosides A-F from extremotolerant lentzea sp H45, a strain isolated from a high-altitude Atacama Desert soil".JOURNAL OF ANTIBIOTICS 70.4(2017):448-453. |
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