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Remote sensing (radar, thermal and topographic) and geophysical (Vertical Electrical Sounding and Ground Penetrating Radar) data are used to understand areas with enhanced groundwater potential in deeper aquifer settings between 22 degrees 0’-22 degrees 56’N and 30 degrees 21-31 degrees 20’E in the Tushka area of southwest Egypt. The premise is that areas with enhanced groundwater accumulations represent the best locations for agricultural development that is underway in this region and that deeper sources groundwater resources are the most sustainable. New fluvial and structural interpretations emphasize that the desert landscape was produced by fluvial action in the past. The correlation of high drainage and fault densities, coincident with gentle slope, guided sites for geophysical investigation that provides information about the aquifer depth and distribution, and the subsurface distribution of faults. Results confirm the presence of subsurface fault plains and fault zones and potential water aquifers at these locations. Surface environments further demonstrated an abundance of shrubs and cultivatable soils. The new approach therefore is a cost effective and noninvasive technique that can be applied throughout the eastern Sahara to assist in resource management decisions and support the planned agricultural expansion. (C) 2017 Elsevier Ltd. All rights reserved.