Arid
DOI10.7150/ijbs.21976
The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair
Wang, Yang1; Li, Dong2; Wang, Gangyang1; Chen, Lulu3,4; Chen, Jun1; Liu, Zhangyin5; Zhang, Zhaofeng1; Shen, Hua1; Jin, Yuqing1; Shen, Zunli1
通讯作者Shen, Hua ; Jin, Yuqing ; Shen, Zunli
来源期刊INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
ISSN1449-2288
出版年2017
卷号13期号:12页码:1507-1519
英文摘要

Combinations of fibroblasts (Fbs) and corresponding epithelial cells have been widely used in many tissues, such as the skin and breast tissues, to augment tissue repair and remodeling. Recently, a large amount of new data has indicated that nerve Fbs play critical roles in Schwann cells (SCs) and axons in vitro. However, little is known regarding the effects of co-transplanting nerve Fbs and SCs on peripheral nerve repair in vivo. The aim of this study was to investigate the effect of co-transplanting sciatic nerve Fbs (SN-Fbs) and sciatic nerve SCs (SN-SCs) on nerve regeneration. We developed a 5 mm nerve-defect model in mice using a polyurethane (PUR) catheter and then injected one of four different mixtures of cells into the catheters to form the following four groups: pure Matrigel (Control group), SN-Fbs alone (SN-Fb group), SN-Fbs combined with SN-SCs at a ratio of 1:2 (Fb&SC group) and SN-SCs alone (SN-SC group). Histological and functional analyses were performed 3 months later. The results indicated that in vitro, the expression levels of NGF, BDNF and GDNF were significantly higher, and in vivo, a more moderate amount of extracellular matrix was produced in the Fb&SC group than in the SN-SC group. Compared to the other groups, co-transplanting SN-Fbs with SCs at a 1:2 ratio had significantly positive effects on nerve regeneration and functional recovery.


英文关键词fibroblasts Schwann cells
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000418365000005
WOS关键词BASAL LAMINA DEPOSITION ; STEM-CELLS ; ENDONEURIAL FIBROBLASTS ; EPIDERMAL REGENERATION ; DESERT HEDGEHOG ; CONDUIT ; DIFFERENTIATION ; MYELINATION ; MIGRATION ; PROMOTES
WOS类目Biochemistry & Molecular Biology ; Biology
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/199708
作者单位1.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China;
2.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai, Peoples R China;
3.Chinese Acad Med Sci, Plast Surg Hosp, Beijing, Peoples R China;
4.Peking Union Med Coll, Beijing, Peoples R China;
5.Jiangpu Primary Hlth Serv Ctr, Shanghai, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yang,Li, Dong,Wang, Gangyang,et al. The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair[J],2017,13(12):1507-1519.
APA Wang, Yang.,Li, Dong.,Wang, Gangyang.,Chen, Lulu.,Chen, Jun.,...&Shen, Zunli.(2017).The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair.INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES,13(12),1507-1519.
MLA Wang, Yang,et al."The effect of co-transplantation of nerve fibroblasts and Schwann cells on peripheral nerve repair".INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 13.12(2017):1507-1519.
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