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Although a widely used forage plant in arid areas, Cenchrus biflorus is viewed by many scientists as an invasive weed that has a serious negative impact on agriculture and biodiversity in arid and semi-arid environments. It has risen from insignificance as a forage and famine cereal crop to its recent status as one of the most economically destructive weeds in many regions of the world. Numerous features like high nutritional value, prolific seed production, tolerance to high temperature and prolonged drought conditions contributed greatly towards its success as a potential forage species in arid environments. But, evidence from agriculturalists shows that it is a destructive invader which disrupts cultural practices and reduces natural biodiversity. Unfortunately, limited knowledge is available about its ecology and management in natural habitats and agro-ecosystems. In this paper, we provide a comprehensive review of its ecology, biology, agricultural impact, management and utilization. This review also provides future directions for research on C.biflorus in arid environments.