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Most areas of arid Asia are covered by aeolian dunes, sand sheets, gravels, and desert steppes, and may jeopardize nearly 350 million people if climate change increases aeolian desertification. Although the aeolian desertification is mainly triggered by climate changes are extensively acknowledged, the responses of aeolian desertification to various climate scenarios are poorly understood. Based on the tight combinations of dune activity index (DAI) trends and of aeolian desertification, here the spatial differences of aeolian desertification responses on various climate scenarios were reported. The analyzed results show that the variations in temperature, precipitation and wind regime have no significant contributions on aeolian desertification in the extremely arid Asia. From the early to blooming periods of vegetation growth, although temperature rise may benefit vegetation growths in some high latitudes and altitudes, the temperature rise may increase aeolian desertification in most arid Asia regions such as Mongolia, West and Central Asia. In arid Asia, although precipitation increases may benefit the rehabilitation, decreases in precipitation is not the key role on aeolian desertification occurrences in extremely arid regions. From the early to blooming periods of vegetation growths, spatial trends of the sensitivity of aeolian desertification to wind regime varied. Generally, at the regional scales there are relative high sensitivities for aeolian desertification to climate changes in the eastern and western regions of arid Asia, and the climate changes may not play important roles on aeolian desertification occurrence in the central regions. The spatial differences of aeolian desertification responses to climate changes indicate various strategies for aeolian desertification combating are needed in different regions of arid Asia. (C) 2016 Elsevier B.V. All rights reserved.