Arid
DOI10.1080/01480545.2016.1242013
Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats
Gao, Yuqiu; Qin, Guangqiu; Wen, Pingjing; Wang, Yanwu; Fu, Weizhong; He, Li; Yao, Siyu; Zhao, Peng
通讯作者Qin, Guangqiu
来源期刊DRUG AND CHEMICAL TOXICOLOGY
ISSN0148-0545
EISSN1525-6014
出版年2017
卷号40期号:4页码:383-389
英文摘要

Cistanche deserticola (C. deserticola), a holoparasitic plant widely distributed in arid or semi-arid areas in Eurasia and North Africa, has been used as an important tonic in traditional Eastern medicine for centuries. However, little information on the systemic toxicity and safety evaluation of it is available. The purpose of this study was to investigate the potential toxicity of powdered C. deserticola as a novel food ingredient by use of a subchronic toxicity study in Sprague-Dawley (SD) rats. A total of 80 male and female rats were fed with diets containing 8, 4, 2 and 0% (control) powdered C. deserticola for 90 days. A toxicological assessment was performed including mortality, body and organ weight, food consumption, blood biochemistry, hematology, gross necropsy and histopathological examinations. There were no signs of toxicity and treatment-related changes in rats treated with powdered C. deserticola. The no-observed-adverse-effect level (NOAEL) of powdered C. deserticola was 7.8 g kg(-1) body weight for males and 8.0 g kg(-1) body weight for females of rats under the experimental conditions of this study.


英文关键词Cistanche deserticola subchronic toxicity feeding study
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000406544200002
WOS关键词TOXICITY ; MICE
WOS类目Chemistry, Multidisciplinary ; Pharmacology & Pharmacy ; Toxicology
WOS研究方向Chemistry ; Pharmacology & Pharmacy ; Toxicology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/198319
作者单位Guangxi Ctr Dis Prevent & Control, Inst Toxicol, 18 Jinzhou Rd, Nanning 530028, Peoples R China
推荐引用方式
GB/T 7714
Gao, Yuqiu,Qin, Guangqiu,Wen, Pingjing,et al. Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats[J],2017,40(4):383-389.
APA Gao, Yuqiu.,Qin, Guangqiu.,Wen, Pingjing.,Wang, Yanwu.,Fu, Weizhong.,...&Zhao, Peng.(2017).Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats.DRUG AND CHEMICAL TOXICOLOGY,40(4),383-389.
MLA Gao, Yuqiu,et al."Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats".DRUG AND CHEMICAL TOXICOLOGY 40.4(2017):383-389.
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