Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1080/01480545.2016.1242013 |
Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats | |
Gao, Yuqiu; Qin, Guangqiu; Wen, Pingjing; Wang, Yanwu; Fu, Weizhong; He, Li; Yao, Siyu; Zhao, Peng | |
通讯作者 | Qin, Guangqiu |
来源期刊 | DRUG AND CHEMICAL TOXICOLOGY
![]() |
ISSN | 0148-0545 |
EISSN | 1525-6014 |
出版年 | 2017 |
卷号 | 40期号:4页码:383-389 |
英文摘要 | Cistanche deserticola (C. deserticola), a holoparasitic plant widely distributed in arid or semi-arid areas in Eurasia and North Africa, has been used as an important tonic in traditional Eastern medicine for centuries. However, little information on the systemic toxicity and safety evaluation of it is available. The purpose of this study was to investigate the potential toxicity of powdered C. deserticola as a novel food ingredient by use of a subchronic toxicity study in Sprague-Dawley (SD) rats. A total of 80 male and female rats were fed with diets containing 8, 4, 2 and 0% (control) powdered C. deserticola for 90 days. A toxicological assessment was performed including mortality, body and organ weight, food consumption, blood biochemistry, hematology, gross necropsy and histopathological examinations. There were no signs of toxicity and treatment-related changes in rats treated with powdered C. deserticola. The no-observed-adverse-effect level (NOAEL) of powdered C. deserticola was 7.8 g kg(-1) body weight for males and 8.0 g kg(-1) body weight for females of rats under the experimental conditions of this study. |
英文关键词 | Cistanche deserticola subchronic toxicity feeding study |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000406544200002 |
WOS关键词 | TOXICITY ; MICE |
WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy ; Toxicology |
WOS研究方向 | Chemistry ; Pharmacology & Pharmacy ; Toxicology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/198319 |
作者单位 | Guangxi Ctr Dis Prevent & Control, Inst Toxicol, 18 Jinzhou Rd, Nanning 530028, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, Yuqiu,Qin, Guangqiu,Wen, Pingjing,et al. Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats[J],2017,40(4):383-389. |
APA | Gao, Yuqiu.,Qin, Guangqiu.,Wen, Pingjing.,Wang, Yanwu.,Fu, Weizhong.,...&Zhao, Peng.(2017).Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats.DRUG AND CHEMICAL TOXICOLOGY,40(4),383-389. |
MLA | Gao, Yuqiu,et al."Safety assessment of powdered Cistanche deserticola Y. C. Ma by a 90-day feeding test in Sprague-Dawley rats".DRUG AND CHEMICAL TOXICOLOGY 40.4(2017):383-389. |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。