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In Egypt, organic-rich sediments in the Duwi and Dakhla Formations of the Campanian-Danian age are customarily assigned as "oil shale" that occupies the middle latitudes of the country but may extend southward to Kurkur Oases. This oil shale belt has a vast worldwide extension, and it is considered as major oil-and gas-prone source rock in many places, especially in the Middle East. The sedimentation of the oil shale was triggered by the major transgression event that occurred during the Late Cretaceous. The lithology, type of kerogen, organic richness, and thickness of these organic-rich sediments vary markedly both on lateral and vertical scales. In Quseir area, the in-place geological reserves, of oil shale of the 800-kcal/kg quality, is estimated to be more than 9 billion tons that can produce 5.48 bbls equivalent upon retorting. Very optimistic resources are expected in the unexplored Nile Valley region. The factor analysis of data rank representing 1176 core samples and analysis of 58 major and trace elements besides Rock-Eval analyses point to five main controlling factors that control deposition of oil shale. The terrestrial indicators Al2O3, TiO2, Fe2O3, and K2O and the marine indicators Ca and Sr are oppositely loaded in the first factor. The second factor expresses the reducing conditions that prevailed during the deposition of the organic-rich marine environments. The euxinity of the basin is recognized by the third factor where sulfide and vanadium seem to be mutual. The fourth factor expresses the role of dolomitization while the fifth factor points to the humble role of oxidation. Considering the metric core samples, the highest TOC content recorded in the borehole drilled in Abu Tartur plateau is 3.6%, but it is about 14% for Quseir area. Regarding the spot samples in Quseir area, the highest TOC measured about 24%. It is not only the low TOC in Abu Tartur but also the kerogen type that is of type II + III, mostly of terrestrial origin (gas-prone) and lithology dominated by argillites. Organic richness is remarkable in Quseir-Safaga area, where the average TOC of 160-m-thick sequence is about 5%, with kerogen of type I or mixed I + II, mostly of marine origin (oil prone). The Dakhla Formation (Maastrichtian-Danian) is the richest in organic matter while Quseir Formation (Campanian) has the least organic richness and lowest kerogen quality. Detailed investigation on biomarkers confirms the relations among transgression, organic richness, kerogen type, and anoxic conditions. The organic matter is immature as witnessed by the low S1 values (<5%, in average), the low T-max (<430 degrees C), the low vitrinite reflectance (<0.4%), and biomarker signature. The variation in the S1 values between 1 and 9% is attributed to the influence of tectonics associating the Red Sea rift. In Quseir-Safaga area, there are particular prolific horizons of oil shale that seem to be visible for utilization by different technologies of combustion and retorting. The content of the heavy metals and uranium, as well as the spent, is a significant benefit. The faulting, dragging, and steep tilting of beds in the Quseir-Safaga area shall remain a serious challenge for extensive utilization of the estimated in-place geological reserves.