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DOI | 10.14744/AnatolJCardiol.2017.7730 |
"Desert" gene (Chr9p21) variants as novel markers for coronary artery disease | |
Shendy, Heba A.; Hassanein, Sally I.; Gad, Mohamed Z. | |
通讯作者 | Gad, Mohamed Z. |
来源期刊 | ANATOLIAN JOURNAL OF CARDIOLOGY |
ISSN | 2149-2263 |
EISSN | 2149-2271 |
出版年 | 2017 |
卷号 | 18期号:2页码:84-89 |
英文摘要 | Objective: Previous reports have denoted to the possible link of Chr9p21 locus to the incidence of coronary artery disease (CAD). The entire core of chr9p21 is covered by "ANRIL" (Antisense noncoding RNA in INK4 Locus) and lies in a region that is free from any coding proteins; therefore, it is called the desert gene. The major objectives of this study were to examine the association of rs10757278 and rs2383206 SNPs on Chr9p21 with the incidence of CAD in the presence and absence of type 2 diabetes (T2D) in Egyptians and to correlate these genetic variants with several disease biomarkers (TC, CRP, and HbA1c). Methods: The study subjects consisted of 150 subjects; 50 healthy controls and 100 patients that were divided into two groups; CAD patients and CAD T2D patients. The genotyping of SNPs was performed using qPCR. Results: Genotype distribution for both SNPs were found to be significantly different (p=0.0009 for rs10757278 and p=0.001 for rs2383206) between patients and controls. The allele frequency was also different for rs10757278. Conclusion: The current study showed that rs10757278/ rs2383206-G allele increases the risk for CAD in Egyptians. Moreover, AA variant appeared as a protective genotype. However, SNPs did not noticeably contribute in the elevation of TC, hs-CRP, and HbA1c in non-diabetic and diabetic CAD patients. |
英文关键词 | Desert gene (Chr9p21) polymorphism Egyptians coronary artery disease |
类型 | Article |
语种 | 英语 |
国家 | Egypt |
收录类别 | SCI-E |
WOS记录号 | WOS:000414035200003 |
WOS关键词 | GENOME-WIDE ASSOCIATION ; C-REACTIVE PROTEIN ; CHROMOSOME 9P21 LOCUS ; MYOCARDIAL-INFARCTION ; SUSCEPTIBILITY LOCI ; RISK ; POLYMORPHISMS ; POPULATION ; CANCER ; SEQUENCE |
WOS类目 | Cardiac & Cardiovascular Systems |
WOS研究方向 | Cardiovascular System & Cardiology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/197287 |
作者单位 | German Univ Cairo, Fac Pharm & Biotechnol, Clin Biochem Unit, Cairo, Egypt |
推荐引用方式 GB/T 7714 | Shendy, Heba A.,Hassanein, Sally I.,Gad, Mohamed Z.. "Desert" gene (Chr9p21) variants as novel markers for coronary artery disease[J],2017,18(2):84-89. |
APA | Shendy, Heba A.,Hassanein, Sally I.,&Gad, Mohamed Z..(2017)."Desert" gene (Chr9p21) variants as novel markers for coronary artery disease.ANATOLIAN JOURNAL OF CARDIOLOGY,18(2),84-89. |
MLA | Shendy, Heba A.,et al.""Desert" gene (Chr9p21) variants as novel markers for coronary artery disease".ANATOLIAN JOURNAL OF CARDIOLOGY 18.2(2017):84-89. |
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