Arid
DOI10.1021/acs.analchem.7b02867
Optimization of the Determination Method for Dissolved Cyanobacterial Toxin BMAA in Natural Water
Yan, Boyin1; Liu, Zhiquan1; Huang, Rui1; Xu, Yongpeng1; Liu, Dongmei1; Lin, Tsair-Fuh2; Cui, Fuyi1
通讯作者Liu, Zhiquan ; Cui, Fuyi
来源期刊ANALYTICAL CHEMISTRY
ISSN0003-2700
EISSN1520-6882
出版年2017
卷号89期号:20页码:10991-10998
英文摘要

There is a serious dispute on the existence of beta-N-methylamino-Lalanine (BMAA) in water, which is a neurotcndn that may cause amyotrophic lateral sclerosis/Parkinson’s disease (ALS/PDC) and Alzheimer’ disease. It is believed that a reliable and sensitive analytical method for the determination of BMAA is urgently required to resolve this dispute. In the present study, the solid phase extraction (SPE) procedure and the analytical method for dissolved BMAA in water were investigated and optimized. The results showed both derivatized and underivatized methods were qualified for the measurement of BMAA and its isomer in natural water, and the limit of detection and the precision of the two methods were comparable. Cartridge characteristics and SPE conditions could greatly affect the SPE performance, and the competition of natural organic matter is the primary factor causing the low recovery of BMAA, which was reduced from approximately 90% in pure water to 38.11% in natural water. The optimized SPE method for BMAA was a combination of rinsed SPE cartridges, controlled loading/elution rates and elution solution, evaporation at 55 degrees C, reconstitution of a solution mixture, and filtration by polyvinylidene fluoride membrane. This optimized method achieved > 88% recovery of BMAA in both algal solution and river water. The developed method can provide an efficient way to evaluate the actual concentration levels of BMAA in actual water environments and drinking water systems.


类型Article
语种英语
国家Peoples R China ; Taiwan
收录类别SCI-E
WOS记录号WOS:000413392500048
WOS关键词METHYLAMINO-L-ALANINE ; TANDEM MASS-SPECTROMETRY ; 2,4-DIAMINOBUTYRIC ACID DAB ; NEUROTOXIC AMINO-ACID ; NEURODEGENERATIVE DISEASE ; INTRAPARTICLE DIFFUSION ; DESERT ENVIRONMENTS ; CHAMORRO PEOPLE ; FRESH-WATER ; PERFORMANCE
WOS类目Chemistry, Analytical
WOS研究方向Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/197285
作者单位1.Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150090, Heilongjiang, Peoples R China;
2.Natl Cheng Kung Univ, Dept Environm Engn, Tainan 701, Taiwan
推荐引用方式
GB/T 7714
Yan, Boyin,Liu, Zhiquan,Huang, Rui,et al. Optimization of the Determination Method for Dissolved Cyanobacterial Toxin BMAA in Natural Water[J],2017,89(20):10991-10998.
APA Yan, Boyin.,Liu, Zhiquan.,Huang, Rui.,Xu, Yongpeng.,Liu, Dongmei.,...&Cui, Fuyi.(2017).Optimization of the Determination Method for Dissolved Cyanobacterial Toxin BMAA in Natural Water.ANALYTICAL CHEMISTRY,89(20),10991-10998.
MLA Yan, Boyin,et al."Optimization of the Determination Method for Dissolved Cyanobacterial Toxin BMAA in Natural Water".ANALYTICAL CHEMISTRY 89.20(2017):10991-10998.
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