Arid
DOI10.1021/acsami.7b01365
"One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer
Peng, Jinrong1; Dong, Mingling1; Ran, Bei1; Li, Wenting2; Hao, Ying1; Yang, Qian3; Tan, Liwei1; Shi, Kun1; Qian, Zhiyong1
通讯作者Qian, Zhiyong
来源期刊ACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
EISSN1944-8252
出版年2017
卷号9期号:16页码:13875-13886
英文摘要

Multiinodal imaging-guided diagnosis arid therapy has been highlighted in the area of theranostic nanomaterials. To proivide more suitable theranostic candidates,. Prussian blue (PB)/manganesedioxide (MiO(2))hybrid nanoparticles (PBMn) smaller than 50 nm are prepared by a one-pot method. MnO2, which is reduced from KMnO4:, not only controls the particle size, the optical properties, and the transverse relaxation rate (r(2)) = of PB but also enhances the catalysis efficacy of,PB to H2O2 for oxygen generation. PBMn can serve as a photoacoustic imaging (PAI) and longitudinal relaxation (T-1) mode magnetic resonance imaging contrast agent (14 times and 1.8 times of the saline-treated group, respectively). Injection of PBMn can regulate the, oxygen partial pressure of the tumor tissue from 2.1 +/- 0.2 to 9.3 +/- 0.4 kPa and rearrange the ratio: of oxygenated hemoglobin and deoxygenate hemoglobin:inside the tumor, which favor the enhancement of the diamagnetic T-2-weighted imaging (T2WI) signal intensity (two times that of the saline-treated group). Furthermore, PBMn-mediated PTT can efficiently inhibit the growth of the MCF-7 tumor in vitro and in vivo. PBMn can serve as a PAI/T-1/T-2 trimodal contrast agent and in imaging-guided PTT, as well as in the oxygen regulation of the exografted breast cancer.


英文关键词Multimodal imaging photothermal therapy hybrid nanoparticles MRI oxygen regulation
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000400321800009
WOS关键词ALL-IN-ONE ; TUMOR HYPOXIA ; HYDROGEN-PEROXIDE ; NANOPARTICLES ; BLUE ; CO ; NANOMATERIALS ; NANOCLUSTERS ; COMBINATION ; TOMOGRAPHY
WOS类目Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向Science & Technology - Other Topics ; Materials Science
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/196940
作者单位1.Sichuan Univ, West China Hosp, State Key Lab & Collaborat Innovat Ctr Biotherapy, 17 Sect 3,Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China;
2.West China Second Univ Hosp, Dept Pharm, 20 Sect 3,Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China;
3.Chengdu Med Coll, Sch Pharm, 783 Xindu Ave, Chengdu 610500, Sichuan, Peoples R China
推荐引用方式
GB/T 7714
Peng, Jinrong,Dong, Mingling,Ran, Bei,et al. "One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer[J],2017,9(16):13875-13886.
APA Peng, Jinrong.,Dong, Mingling.,Ran, Bei.,Li, Wenting.,Hao, Ying.,...&Qian, Zhiyong.(2017)."One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer.ACS APPLIED MATERIALS & INTERFACES,9(16),13875-13886.
MLA Peng, Jinrong,et al.""One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer".ACS APPLIED MATERIALS & INTERFACES 9.16(2017):13875-13886.
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