Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1021/acsami.7b01365 |
"One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer | |
Peng, Jinrong1; Dong, Mingling1; Ran, Bei1; Li, Wenting2; Hao, Ying1; Yang, Qian3; Tan, Liwei1; Shi, Kun1; Qian, Zhiyong1 | |
通讯作者 | Qian, Zhiyong |
来源期刊 | ACS APPLIED MATERIALS & INTERFACES
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ISSN | 1944-8244 |
EISSN | 1944-8252 |
出版年 | 2017 |
卷号 | 9期号:16页码:13875-13886 |
英文摘要 | Multiinodal imaging-guided diagnosis arid therapy has been highlighted in the area of theranostic nanomaterials. To proivide more suitable theranostic candidates,. Prussian blue (PB)/manganesedioxide (MiO(2))hybrid nanoparticles (PBMn) smaller than 50 nm are prepared by a one-pot method. MnO2, which is reduced from KMnO4:, not only controls the particle size, the optical properties, and the transverse relaxation rate (r(2)) = of PB but also enhances the catalysis efficacy of,PB to H2O2 for oxygen generation. PBMn can serve as a photoacoustic imaging (PAI) and longitudinal relaxation (T-1) mode magnetic resonance imaging contrast agent (14 times and 1.8 times of the saline-treated group, respectively). Injection of PBMn can regulate the, oxygen partial pressure of the tumor tissue from 2.1 +/- 0.2 to 9.3 +/- 0.4 kPa and rearrange the ratio: of oxygenated hemoglobin and deoxygenate hemoglobin:inside the tumor, which favor the enhancement of the diamagnetic T-2-weighted imaging (T2WI) signal intensity (two times that of the saline-treated group). Furthermore, PBMn-mediated PTT can efficiently inhibit the growth of the MCF-7 tumor in vitro and in vivo. PBMn can serve as a PAI/T-1/T-2 trimodal contrast agent and in imaging-guided PTT, as well as in the oxygen regulation of the exografted breast cancer. |
英文关键词 | Multimodal imaging photothermal therapy hybrid nanoparticles MRI oxygen regulation |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000400321800009 |
WOS关键词 | ALL-IN-ONE ; TUMOR HYPOXIA ; HYDROGEN-PEROXIDE ; NANOPARTICLES ; BLUE ; CO ; NANOMATERIALS ; NANOCLUSTERS ; COMBINATION ; TOMOGRAPHY |
WOS类目 | Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/196940 |
作者单位 | 1.Sichuan Univ, West China Hosp, State Key Lab & Collaborat Innovat Ctr Biotherapy, 17 Sect 3,Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China; 2.West China Second Univ Hosp, Dept Pharm, 20 Sect 3,Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China; 3.Chengdu Med Coll, Sch Pharm, 783 Xindu Ave, Chengdu 610500, Sichuan, Peoples R China |
推荐引用方式 GB/T 7714 | Peng, Jinrong,Dong, Mingling,Ran, Bei,et al. "One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer[J],2017,9(16):13875-13886. |
APA | Peng, Jinrong.,Dong, Mingling.,Ran, Bei.,Li, Wenting.,Hao, Ying.,...&Qian, Zhiyong.(2017)."One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer.ACS APPLIED MATERIALS & INTERFACES,9(16),13875-13886. |
MLA | Peng, Jinrong,et al.""One-for-AII"-Type, Biodegradable Prussian Blue/Manganese Dioxide Hybrid Nanocrystal for Trimodal Imaging-Guided Photothermal Therapy and Oxygen Regulation of Breast Cancer".ACS APPLIED MATERIALS & INTERFACES 9.16(2017):13875-13886. |
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