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Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry
Al-Qaim, Fouad Fadhil1,2; Abdullah, Md Pauzi1; Latip, Jalifah1; Khalik, Wan Mohd Afiq Wan Mohd1; Abu Tahrim, Nurfaizah1; Abidin, Nurul Auni Zainal1; Othman, Mohamed Rozali1,3
通讯作者Othman, Mohamed Rozali
来源期刊SAINS MALAYSIANA
ISSN0126-6039
出版年2016
卷号45期号:5页码:803-810
英文摘要

The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was applied to analysis of gliclazide (diabetic drug) in surface water and wastewater from sewage treatment plants and hospitals. The proposed analytical method allows simultaneous isolation and concentration procedure using solid phase extraction (Oasis HLB) prior to separation using high-performance liquid chromatography. The detection and confirmation was achieved by applying time-of-flight analyzer. The limits of quantification were as low as 1.4 ng/L (deionized water), 4 ng/L (surface water), 27 ng/L (hospital influent), 10 ng/L (hospital effluent), 6 ng/L (sewage treatment plant effluent) and 21 ng/L (sewage treatment plant influent), respectively. On average, good recoveries of higher than 87% were obtained for gliclazide in the studied samples. The proposed method successfully determined and quantified gliclazide in surface water and wastewater. The results showed that gliclazide is a persistent compound in sewage treatment effluents as well as in the recipient rivers. Gliclazide was detected in all samples and the highest concentration was 130 ng/L in influent of sewage treatment plant.


英文关键词Effluent hospital gliclazide positive ionization solid phase extraction
类型Article
语种英语
国家Malaysia ; Iraq
收录类别SCI-E
WOS记录号WOS:000378347100017
WOS关键词TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; SEWAGE-TREATMENT PLANTS ; WASTE-WATER ; ACIDIC PHARMACEUTICALS ; BASIC PHARMACEUTICALS ; SURFACE-WATER ; RIVER WATER ; EFFLUENTS ; DRUGS
WOS类目Multidisciplinary Sciences
WOS研究方向Science & Technology - Other Topics
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/196155
作者单位1.Univ Kebangsaan Malaysia, Sch Chem Sci & Food Technol, Fac Sci & Technol, Bangi 43600, Selangor Darul, Malaysia;
2.Babylon Univ, Dept Chem, Fac Sci Women, POB 4, Hilla, Iraq;
3.Univ Kebangsaan Malaysia, Ctr Water Res & Anal ALIR, Fac Sci & Technol, Bangi 43600, Selangor Darul, Malaysia
推荐引用方式
GB/T 7714
Al-Qaim, Fouad Fadhil,Abdullah, Md Pauzi,Latip, Jalifah,et al. Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry[J],2016,45(5):803-810.
APA Al-Qaim, Fouad Fadhil.,Abdullah, Md Pauzi.,Latip, Jalifah.,Khalik, Wan Mohd Afiq Wan Mohd.,Abu Tahrim, Nurfaizah.,...&Othman, Mohamed Rozali.(2016).Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry.SAINS MALAYSIANA,45(5),803-810.
MLA Al-Qaim, Fouad Fadhil,et al."Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry".SAINS MALAYSIANA 45.5(2016):803-810.
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