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Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry | |
Al-Qaim, Fouad Fadhil1,2; Abdullah, Md Pauzi1; Latip, Jalifah1; Khalik, Wan Mohd Afiq Wan Mohd1; Abu Tahrim, Nurfaizah1; Abidin, Nurul Auni Zainal1; Othman, Mohamed Rozali1,3 | |
通讯作者 | Othman, Mohamed Rozali |
来源期刊 | SAINS MALAYSIANA
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ISSN | 0126-6039 |
出版年 | 2016 |
卷号 | 45期号:5页码:803-810 |
英文摘要 | The big challenge for the detection of pharmaceutical residues in water samples is the type of ionization mode in terms of positive or negative ionization which plays an important role to identify and quantify the analytes using liquid chromatography/mass spectrometry. An analytical method was applied to analysis of gliclazide (diabetic drug) in surface water and wastewater from sewage treatment plants and hospitals. The proposed analytical method allows simultaneous isolation and concentration procedure using solid phase extraction (Oasis HLB) prior to separation using high-performance liquid chromatography. The detection and confirmation was achieved by applying time-of-flight analyzer. The limits of quantification were as low as 1.4 ng/L (deionized water), 4 ng/L (surface water), 27 ng/L (hospital influent), 10 ng/L (hospital effluent), 6 ng/L (sewage treatment plant effluent) and 21 ng/L (sewage treatment plant influent), respectively. On average, good recoveries of higher than 87% were obtained for gliclazide in the studied samples. The proposed method successfully determined and quantified gliclazide in surface water and wastewater. The results showed that gliclazide is a persistent compound in sewage treatment effluents as well as in the recipient rivers. Gliclazide was detected in all samples and the highest concentration was 130 ng/L in influent of sewage treatment plant. |
英文关键词 | Effluent hospital gliclazide positive ionization solid phase extraction |
类型 | Article |
语种 | 英语 |
国家 | Malaysia ; Iraq |
收录类别 | SCI-E |
WOS记录号 | WOS:000378347100017 |
WOS关键词 | TANDEM MASS-SPECTROMETRY ; SOLID-PHASE EXTRACTION ; SEWAGE-TREATMENT PLANTS ; WASTE-WATER ; ACIDIC PHARMACEUTICALS ; BASIC PHARMACEUTICALS ; SURFACE-WATER ; RIVER WATER ; EFFLUENTS ; DRUGS |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/196155 |
作者单位 | 1.Univ Kebangsaan Malaysia, Sch Chem Sci & Food Technol, Fac Sci & Technol, Bangi 43600, Selangor Darul, Malaysia; 2.Babylon Univ, Dept Chem, Fac Sci Women, POB 4, Hilla, Iraq; 3.Univ Kebangsaan Malaysia, Ctr Water Res & Anal ALIR, Fac Sci & Technol, Bangi 43600, Selangor Darul, Malaysia |
推荐引用方式 GB/T 7714 | Al-Qaim, Fouad Fadhil,Abdullah, Md Pauzi,Latip, Jalifah,et al. Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry[J],2016,45(5):803-810. |
APA | Al-Qaim, Fouad Fadhil.,Abdullah, Md Pauzi.,Latip, Jalifah.,Khalik, Wan Mohd Afiq Wan Mohd.,Abu Tahrim, Nurfaizah.,...&Othman, Mohamed Rozali.(2016).Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry.SAINS MALAYSIANA,45(5),803-810. |
MLA | Al-Qaim, Fouad Fadhil,et al."Detection of Gliclazide in Aqueous Samples using Liquid Chromatography/Time-of-Flight/Mass Spectrometry".SAINS MALAYSIANA 45.5(2016):803-810. |
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