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The land-cover changes in the cloud forest and coastal plain of Dhofar, Oman, from 1988 to 2013 are reported, and their possible causes explored. Multiple endmember spectral mixture analysis, cluster analysis using local indicators of spatial association, and trend analysis of NDVI time series are used to measure environmental changes. The results demonstrate: systematic degradation and loss of vegetation types in the cloud forest; loss of native land covers to impervious surfaces on the coastal plain; decreases in woody plant vegetation in almost half of the cloud forest in distinctive hotspots of loss; and significant decreases in NDVI trends around the city of Salalah, along the coastal plain, and in parts of the cloud forest. The proximate drivers of these changes in the cloud forest appear to be changes in grazing activities, while the growth of Salalah, especially its peri-urban area, altered the coastal plain. These drivers, in turn, are linked to distal ones, foremost changes in Omani policies and investments in the Dhofar area, traced to government responses to the Dhofar War (1970-1975), which have resulted in increased livestock populations and urban growth.