Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1371/journal.pone.0161468 |
Arid3b Is Critical for B Lymphocyte Development | |
Kurkewich, Jeffrey L.1,2; Klopfenstein, Nathan2,4; Hallas, William M.2,5; Wood, Christian1,2; Sattler, Rachel A.2,6; Das, Chhaya3; Tucker, Haley; Dahl, Richard1,2,4; Dahl, Karen D. Cowden2,5,6 | |
通讯作者 | Dahl, Richard ; Dahl, Karen D. Cowden |
来源期刊 | PLOS ONE
![]() |
ISSN | 1932-6203 |
出版年 | 2016 |
卷号 | 11期号:8 |
英文摘要 | Arid3a and Arid3b belong to a subfamily of ARID (AT-rich interaction domain) transcription factors. The Arid family is involved in regulating chromatin accessibility, proliferation, and differentiation. Arid3a and Arid3b are closely related and share a unique REKLES domain that mediates their homo- and hetero-multimerization. Arid3a was originally isolated as a B cell transcription factor binding to the AT rich matrix attachment regions (MARS) of the immunoglobulin heavy chain intronic enhancer. Deletion of Arid3a results in a highly penetrant embryonic lethality with severe defects in erythropoiesis and hematopoietic stem cells (HSCs). The few surviving Arid3a(-/-) (<1%) animals have decreased HSCs and early progenitors in the bone marrow, but all mature lineages are normally represented in the bone marrow and periphery except for B cells. Arid3b(-/-) animals die around E7.5 precluding examination of hematopoietic development. So it is unclear whether the phenotype of Arid3a loss on hematopoiesis is dependent or independent of Arid3b. In this study we circumvented this limitation by also examining hematopoiesis in mice with a conditional allele of Arid3b. Bone marrow lacking Arid3b shows decreased common lymphoid progenitors (CLPs) and downstream B cell populations while the T cell and myeloid lineages are unchanged, reminiscent of the adult hematopoietic defect in Arid3a mice. Unlike Arid3a(-/-) mice, HSC populations are unperturbed in Arid3b(-/-) mice. This study demonstrates that HSC development is independent of Arid3b, whereas B cell development requires both Arid3a and Arid3b transcription factors. |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000381577000109 |
WOS关键词 | MOUSE BONE-MARROW ; IN-VITRO ; CELL ; TRANSCRIPTION ; EXPRESSION ; BRIGHT ; RESPONSES ; DEFECTS ; FAMILY ; CANCER |
WOS类目 | Multidisciplinary Sciences |
WOS研究方向 | Science & Technology - Other Topics |
来源机构 | Arizona State University |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/195654 |
作者单位 | 1.Univ Notre Dame, Dept Biol Sci, Notre Dame, IN 46556 USA; 2.Harper Canc Res Inst, South Bend, IN 46617 USA; 3.Univ Texas Austin, Dept Mol Biosci, Inst Cellular & Mol Biol, Austin, TX 78712 USA; 4.Indiana Univ Sch Med, Dept Microbiol & Immunol, South Bend, IN 46617 USA; 5.Indiana Univ Sch Med, Dept Biochem & Mol Biol, South Bend, IN 46617 USA; 6.Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA |
推荐引用方式 GB/T 7714 | Kurkewich, Jeffrey L.,Klopfenstein, Nathan,Hallas, William M.,et al. Arid3b Is Critical for B Lymphocyte Development[J]. Arizona State University,2016,11(8). |
APA | Kurkewich, Jeffrey L..,Klopfenstein, Nathan.,Hallas, William M..,Wood, Christian.,Sattler, Rachel A..,...&Dahl, Karen D. Cowden.(2016).Arid3b Is Critical for B Lymphocyte Development.PLOS ONE,11(8). |
MLA | Kurkewich, Jeffrey L.,et al."Arid3b Is Critical for B Lymphocyte Development".PLOS ONE 11.8(2016). |
条目包含的文件 | 条目无相关文件。 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。