Arid
DOI10.1371/journal.pntd.0004885
Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil
Souto, Ana C. P.1; Bonfietti, Lucas X.2; Ferreira-Paim, Kennio3,4; Trilles, Luciana1,3; Martins, Marilena2; Ribeiro-Alves, Marcelo1; Pham, Cau D.5; Martins, Liline6; dos Santos, Wallace1,3,7; Chang, Marilene8; Brito-Santos, Fabio1; Santos, Dayane C. S.2; Fortes, Silvana9; Lockhart, Shawn R.5; Wanke, Bodo1; Melhem, Marcia S. C.2; Lazera, Marcia S.1; Meyer, Wieland1,3
通讯作者Meyer, Wieland
来源期刊PLOS NEGLECTED TROPICAL DISEASES
ISSN1935-2735
出版年2016
卷号10期号:8
英文摘要

Cryptococcus neoformans and Cryptococcus gattii are responsible globally for almost one million cryptococcosis cases yearly, mostly in immunocompromised patients, such as those living with HIV. Infections due to C. gattii have mainly been described in tropical and subtropical regions, but its adaptation to temperate regions was crucial in the species evolution and highlighted the importance of this pathogenic yeast in the context of disease. Cryptococcus gattii molecular type VGII has come to the forefront in connection with an on-going emergence in the Pacific North West of North America. Taking into account that previous work pointed towards South America as an origin of this species, the present work aimed to assess the genetic diversity within the Brazilian C. gattii VGII population in order to gain new insights into its origin and global dispersal from the South American continent using the ISHAM consensus MLST typing scheme. Our results corroborate the finding that the Brazilian C. gattii VGII population is highly diverse. The diversity is likely due to recombination generated from sexual reproduction, as evidenced by the presence of both mating types in clinical and environmental samples. The data presented herein strongly supports the emergence of highly virulent strains from ancestors in the Northern regions of Brazil, Amazonia and the Northeast. Numerous genotypes represent a link between Brazil and other parts of the world reinforcing South America as the most likely origin of the C. gattii VGII subtypes and their subsequent global spread, including their dispersal into North America, where they caused a major emergence.


类型Article
语种英语
国家Brazil ; Australia ; USA
收录类别SCI-E
WOS记录号WOS:000382390800029
WOS关键词NEOFORMANS VAR. GATTII ; MULTILOCUS GENOTYPE DATA ; VANCOUVER-ISLAND ; SPECIES COMPLEX ; MOLECULAR EPIDEMIOLOGY ; CANADA ; EVOLUTIONARY ; INFERENCE ; OUTBREAK ; RECOMBINATION
WOS类目Infectious Diseases ; Parasitology ; Tropical Medicine
WOS研究方向Infectious Diseases ; Parasitology ; Tropical Medicine
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/195580
作者单位1.Fundacao Oswaldo Cruz, Evandro Chagas Natl Inst Infect Dis, Rio De Janeiro, Brazil;
2.Adolfo Lutz Inst, Sao Paulo, Brazil;
3.Univ Sydney, Mol Mycol Res Lab,Westmead Med Res, Ctr Infect Dis & Microbiol,Sydney Med School,West, Marie Bashir Inst Emerging Infect Dis & Biosecur, Sydney, NSW, Australia;
4.Triangulo Mineiro Fed Univ, Dept Infect Dis, Uberaba, Brazil;
5.Ctr Dis Control & Prevent, Atlanta, GA USA;
6.Univ Piaui State, Teresina, Brazil;
7.Fed Univ Para, Belem, Para, Brazil;
8.Univ Fed Mato Grosso do Sul, Campo Grande, Brazil;
9.Univ Fed Roraima, Biodivers Res Ctr, Boa Vista, Brazil
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GB/T 7714
Souto, Ana C. P.,Bonfietti, Lucas X.,Ferreira-Paim, Kennio,et al. Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil[J],2016,10(8).
APA Souto, Ana C. P..,Bonfietti, Lucas X..,Ferreira-Paim, Kennio.,Trilles, Luciana.,Martins, Marilena.,...&Meyer, Wieland.(2016).Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil.PLOS NEGLECTED TROPICAL DISEASES,10(8).
MLA Souto, Ana C. P.,et al."Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian Cryptococcus gattii VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil".PLOS NEGLECTED TROPICAL DISEASES 10.8(2016).
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