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Land use change has a significant effect on water balance, especially in arid region, such as Northwest China. In this paper, we analyze the effect of land use change on water balance in terms of the amount of water supply and demand from economic perspective. It’s the first time to extend the basic 48 sectors input-output table to include water and land accounts that involved into multiple production processes for Zhangye city. We then perform the improved ORANI-G model, a single region Computable General Equilibrium (CGE) model, to analyze the effect of land use change on water balance under three scenarios. Subsequently, scenario-based simulation results are interpreted through selected sectors from agricultural, industrial, and service sectors respectively. Finally, the effect of land use change on.water balance is analyzed through the difference between business-as-usual and land use unchanged scenarios. the results show that the extent of effect on water balance is different among sectors. Specifically, from the perspective of absolute value, service sectors are the largest, followed by industrial sectors, and the agricultural sectors are the least. Conversely, in terms of percentage change of land use, the largest extent of effect occurs in agricultural sectors. Additionally, with the rapid urbanization and the development of social economy, water balance in industrial sectors and service sectors will be stricken and reconstructed to a new high level. Simulation results also show that agricultural land shrinking will mitigate water scarcity distinctly, which indicates that balance the relationship among different stakeholders is imperative to guarantee water transformation from agricultural sectors to industrial and service sectors. (C) 2016 Elsevier Ltd. All rights reserved.