Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.peptides.2016.03.002 |
Insulin receptor regulates food intake through sulfakinin signaling in the red flour beetle, Tribolium castaneum | |
Lin, Xianyu; Yu, Na; Smagghe, Guy | |
通讯作者 | Smagghe, Guy |
来源期刊 | PEPTIDES
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ISSN | 0196-9781 |
EISSN | 1873-5169 |
出版年 | 2016 |
卷号 | 80页码:89-95 |
英文摘要 | Insects obtain energy and nutrients via feeding to support growth and development. The insulin signaling pathway is involved in the regulation of feeding; however, the underlying mechanisms are not fully understood. Here, we show that insulin signaling regulates food intake via crosstalk with neuropeptide sulfakinin in the red flour beetle, Tribolium castaneum. Silencing of the insulin receptor (InR) decreased the food intake in the penultimate and final instar stages, leading to a decrease of weight gain and mortality during larval-pupal metamorphosis. Interestingly, the knockdown of InR co-occurred with an increased expression of sulfakinin (sk), a gene encoding neuropeptide SK functioning as a satiety signal. In parallel, double silencing of sk and InR eliminated the inhibitory effect on food intake as induced by silencing of InR and the larvae died as prepupae. In conclusion, this study shows, for the first time, that the insulin/InR signaling regulates food intake through the sulfakinin signaling pathway in the larval stages of this important model and pest insect, indicating a novel target for pest control. (C) 2016 Elsevier Inc. All rights reserved. |
英文关键词 | Insulin receptor Food intake Sulfakinin RNA interference Tribolium castaneum |
类型 | Article ; Proceedings Paper |
语种 | 英语 |
国家 | Belgium |
收录类别 | SCI-E ; CPCI-S |
WOS记录号 | WOS:000375936400012 |
WOS关键词 | GENE-EXPRESSION ; DESERT LOCUST ; LIFE-SPAN ; DROSOPHILA ; GROWTH ; CELLS ; NEURONS ; IDENTIFICATION ; PEPTIDES ; BEHAVIOR |
WOS类目 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy |
WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Pharmacology & Pharmacy |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/195405 |
作者单位 | Univ Ghent, Dept Crop Protect, Lab Agrozool, Coupure Links 653, B-9000 Ghent, Belgium |
推荐引用方式 GB/T 7714 | Lin, Xianyu,Yu, Na,Smagghe, Guy. Insulin receptor regulates food intake through sulfakinin signaling in the red flour beetle, Tribolium castaneum[J],2016,80:89-95. |
APA | Lin, Xianyu,Yu, Na,&Smagghe, Guy.(2016).Insulin receptor regulates food intake through sulfakinin signaling in the red flour beetle, Tribolium castaneum.PEPTIDES,80,89-95. |
MLA | Lin, Xianyu,et al."Insulin receptor regulates food intake through sulfakinin signaling in the red flour beetle, Tribolium castaneum".PEPTIDES 80(2016):89-95. |
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