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Taxonomic study of Quaternary mammal remains from the Qalehjough fossil site, eastern Iran, has resulted in the identification of two mammal orders, Artiodactyla and Perissodactyla, with four families and six taxa. Of particular note was the recovery of Stephanorhinus and a caballoid horse. These remains have provided the first opportunity to examine Late Quaternary faunal assemblages in the northern parts of the Lut Desert, eastern Iran. The Qalehjough faunal assemblage documents some zoogeographic characteristics of the eastern Iranian Plateau, and suggests that palaeoenvironments in this part of Iran during the Pleistocene were more humid and wooded than today. The disappearance of rhinoceroses and caballoid horses from this region is most likely a result of climate change and concomitant habitat loss.