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The dromedary camels are considered as the best livestock animals in arid, semiarid and desert areas and camel milk is known as the valuable food source in these areas. The present study was aimed to investigate milk somatic cell counts and some biochemical changes in milk due to sub-clinical mastitis in camels. For this purpose milk samples were collected from 33 lactating animals and examined for sub clinical mastitis using California Mastitis Test. The chi-square and frequency analysis did not show any significant association with age, lactation stage, parity and quarter involved. The results indicated significant (P<0.01) increase in milk electrical conductivity and milk pH while significantly lower values for milk proteins, lactose and fat contents were recorded. The results revealed that the total milk somatic cell and neutrophil counts were significantly increased while the lymphocytes and macrophages were decreased in infected animals. Moreover, milk enzymes; aspartate aminotransferase, lactate dehydrogenase, and alkaline phosphatase were significantly increased in mastitic animals as compared to the non-infected animals. The results indicated that milk electrical conductivity and some milk enzymes can be screened to investigate the sub-clinical mastitis in Camelus dromedaries. (C) 2016 PVJ. All rights reserved