Arid
Evaluation of Antiviral Potential of Different Cholistani Plants against Infectious Bursal Disease and Infectious Bronchitis Virus
Aslam, Amna1; Shahzad, Mirza Imran2; Parveen, Sabeeha1; Ashraf, Hina3; Naz, Nargis1; Zehra, Syeda Sadaf1; Kamran, Zahid2; Qayyum, Abdul2; Mukhtar, Muhammad4
通讯作者Shahzad, Mirza Imran
来源期刊PAKISTAN VETERINARY JOURNAL
ISSN0253-8318
EISSN2074-7764
出版年2016
卷号36期号:3页码:302-306
英文摘要

The present study was conducted to determine the antiviral activity of different Cholistani plants growing in the Cholistan Desert, Pakistan. Methanolic extracts of plants were prepared by dissolving air-dried, powdered plants in methanol and later concentrated in a rotary evaporator. The concentrated extracts were dissolved in distilled water and sterilized through filtration. To asses antiviral potential plant extracts were mixed with an equal concentration of a live virus and propagated for 7-11 days in embryonated eggs with appropriate controls. After 48 hours, the allantoic fluids were harvested and hemagglutination assay (HA) was performed for infectious bronchitis virus (IBV) and indirect hemagglutination assay (IHA) for infectious bursal disease virus (IBDV) to determine both virus titer, as well as evaluation of the inhibitory effects of various plant extracts. Almost all selected plant extracts exhibited an antiviral effect varying from plant to plant and manifested through controlling growth of IBV except Solanum surattense. The methanolic extracts of two plants Ochthochloa compressa and Sporobolos icolados, showed a 100% inhibitory effect demonstrated through no viral growth determined by HA assays. Similarly, other plant extracts also showed antiviral activity in the order of HA titer at 8 in case of three plants Haloxylon salicornicum, Neurada procumbens and Salsola baryosma, 16 for Achyranthes aspera, Haloxylon recurvum and Panicum antidotale. The HA values 32 and 64, respectively, for Oxystelma esculentum and Suaeda fruticosa were revealed. In case of anti-IBDV activity, the methanolic extracts of Achyranthes aspera, Haloxylon recurvum, Haloxylon salicornicum, Panicum antidotale, Salsola baryosma, Sporobolos icolados were shown to have the optimal antiviral potential (IHA titer 0). Similarly, extract of Neurada procumbens kept the IHA titer at 2 and Solanum surattense at 4. The extracts of Oxystelma esculentum and Ochthochloa compressa were least effective in controlling multiplication of IBDV and their IHA titer was equal to virus control. Overall, our studies open up new avenues in the development of much needed antivirals, utilizing indigenous resources. (C) 2016 PVJ. All rights reserved.


英文关键词Antiviral Activity Cholistan IBDV IBV Medicinal plants
类型Article
语种英语
国家Pakistan ; U Arab Emirates
收录类别SCI-E
WOS记录号WOS:000380062400010
WOS关键词MEDICINAL-PLANTS
WOS类目Veterinary Sciences
WOS研究方向Veterinary Sciences
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/195310
作者单位1.Islamia Univ Bahawalpur, Dept Life Sci, Rahim Yar Khan, Pakistan;
2.Islamia Univ Bahawalpur, Univ Coll Vet & Anim Sci, Rahim Yar Khan, Pakistan;
3.Govt Sadiq Coll Women Univ, Bahawalpur, Pakistan;
4.Amer Univ Ras Al Khaimah, Dept Biotechnol, Ras Al Khaymah, U Arab Emirates
推荐引用方式
GB/T 7714
Aslam, Amna,Shahzad, Mirza Imran,Parveen, Sabeeha,et al. Evaluation of Antiviral Potential of Different Cholistani Plants against Infectious Bursal Disease and Infectious Bronchitis Virus[J],2016,36(3):302-306.
APA Aslam, Amna.,Shahzad, Mirza Imran.,Parveen, Sabeeha.,Ashraf, Hina.,Naz, Nargis.,...&Mukhtar, Muhammad.(2016).Evaluation of Antiviral Potential of Different Cholistani Plants against Infectious Bursal Disease and Infectious Bronchitis Virus.PAKISTAN VETERINARY JOURNAL,36(3),302-306.
MLA Aslam, Amna,et al."Evaluation of Antiviral Potential of Different Cholistani Plants against Infectious Bursal Disease and Infectious Bronchitis Virus".PAKISTAN VETERINARY JOURNAL 36.3(2016):302-306.
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