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DOI10.1016/j.neuroscience.2016.06.024
MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT
Shiramatsu, Tomoyo Isoguchi1; Takahashi, Kazusa1,2,4; Noda, Takahiro1,5; Kanzaki, Ryohei1; Nakahara, Haruka3,6; Takahashi, Hirokazu1
通讯作者Takahashi, Hirokazu
来源期刊NEUROSCIENCE
ISSN0306-4522
EISSN1873-7544
出版年2016
卷号332页码:38-52
英文摘要

The rat has long been considered an important model system for studying neural mechanisms of auditory perception and learning, and particularly mechanisms involving auditory thalamo-cortical processing. However, the functional topography of the auditory thalamus, or medial geniculate body (MGB) has not yet been fully characterized in the rat, and the anatomically-defined features of field-specific, layer-specific and tonotopic thalamo-cortical projections have never been confirmed electrophysiologically. In the present study, we have established a novel technique for recording simultaneously from a surface microelectrode array on the auditory cortex, and a depth electrode array across auditory cortical layers and within the MGB, and characterized the rat MGB and thalamocortical projections under isoflurane anesthesia. We revealed that the ventral division of the MGB (MGv) exhibited a low-high-low CF gradient arid long-short-long latency gradient along the dorsolateral-to-ventromedial axis, suggesting that the rat MGv is divided into two subdivisions. We also demonstrated that microstimulation in the MGv elicited cortical activation in layer-specific, region-specific and tonotopically organized manners. To our knowledge, the present study has provided the first and most compelling electrophysiological confirmation of the anatomical organization of the primary thalamo-cortical pathway in the rat, setting the groundwork for further investigation. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.


英文关键词auditory cortex auditory thalamus microelectrode array thalamo-cortical system tonotopic map
类型Article
语种英语
国家Japan ; Germany
收录类别SCI-E
WOS记录号WOS:000381329800004
WOS关键词MEDIAL GENICULATE-BODY ; PRIMARY AUDITORY-CORTEX ; STIMULUS-SPECIFIC ADAPTATION ; EVOKED-POTENTIALS ; RESPONSE PROPERTIES ; RECEPTIVE-FIELDS ; TEMPORAL CORTEX ; STRIATE CORTEX ; CORTICAL FIELD ; AWAKE MONKEY
WOS类目Neurosciences
WOS研究方向Neurosciences & Neurology
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/195208
作者单位1.Univ Tokyo, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan;
2.Univ Tokyo, Grad Sch Informat Sci & Technol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan;
3.Teikyo Univ, Sch Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan;
4.Komatsu Ltd, Minato Ku, 2-3-6 Akasaka, Tokyo 1078414, Japan;
5.Tech Univ Muinch, Inst Neurosci, Arcisstr 21, D-80333 Munich, Germany;
6.Edogawabashi Clin, Bunkyo Ku, 1-19-6 Sekiguchi, Tokyo 1120014, Japan
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Shiramatsu, Tomoyo Isoguchi,Takahashi, Kazusa,Noda, Takahiro,et al. MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT[J],2016,332:38-52.
APA Shiramatsu, Tomoyo Isoguchi,Takahashi, Kazusa,Noda, Takahiro,Kanzaki, Ryohei,Nakahara, Haruka,&Takahashi, Hirokazu.(2016).MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT.NEUROSCIENCE,332,38-52.
MLA Shiramatsu, Tomoyo Isoguchi,et al."MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT".NEUROSCIENCE 332(2016):38-52.
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