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DOI | 10.1016/j.neuroscience.2016.06.024 |
MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT | |
Shiramatsu, Tomoyo Isoguchi1; Takahashi, Kazusa1,2,4; Noda, Takahiro1,5; Kanzaki, Ryohei1; Nakahara, Haruka3,6; Takahashi, Hirokazu1 | |
通讯作者 | Takahashi, Hirokazu |
来源期刊 | NEUROSCIENCE
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ISSN | 0306-4522 |
EISSN | 1873-7544 |
出版年 | 2016 |
卷号 | 332页码:38-52 |
英文摘要 | The rat has long been considered an important model system for studying neural mechanisms of auditory perception and learning, and particularly mechanisms involving auditory thalamo-cortical processing. However, the functional topography of the auditory thalamus, or medial geniculate body (MGB) has not yet been fully characterized in the rat, and the anatomically-defined features of field-specific, layer-specific and tonotopic thalamo-cortical projections have never been confirmed electrophysiologically. In the present study, we have established a novel technique for recording simultaneously from a surface microelectrode array on the auditory cortex, and a depth electrode array across auditory cortical layers and within the MGB, and characterized the rat MGB and thalamocortical projections under isoflurane anesthesia. We revealed that the ventral division of the MGB (MGv) exhibited a low-high-low CF gradient arid long-short-long latency gradient along the dorsolateral-to-ventromedial axis, suggesting that the rat MGv is divided into two subdivisions. We also demonstrated that microstimulation in the MGv elicited cortical activation in layer-specific, region-specific and tonotopically organized manners. To our knowledge, the present study has provided the first and most compelling electrophysiological confirmation of the anatomical organization of the primary thalamo-cortical pathway in the rat, setting the groundwork for further investigation. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved. |
英文关键词 | auditory cortex auditory thalamus microelectrode array thalamo-cortical system tonotopic map |
类型 | Article |
语种 | 英语 |
国家 | Japan ; Germany |
收录类别 | SCI-E |
WOS记录号 | WOS:000381329800004 |
WOS关键词 | MEDIAL GENICULATE-BODY ; PRIMARY AUDITORY-CORTEX ; STIMULUS-SPECIFIC ADAPTATION ; EVOKED-POTENTIALS ; RESPONSE PROPERTIES ; RECEPTIVE-FIELDS ; TEMPORAL CORTEX ; STRIATE CORTEX ; CORTICAL FIELD ; AWAKE MONKEY |
WOS类目 | Neurosciences |
WOS研究方向 | Neurosciences & Neurology |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/195208 |
作者单位 | 1.Univ Tokyo, Res Ctr Adv Sci & Technol, Meguro Ku, 4-6-1 Komaba, Tokyo 1538904, Japan; 2.Univ Tokyo, Grad Sch Informat Sci & Technol, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan; 3.Teikyo Univ, Sch Med, Itabashi Ku, 2-11-1 Kaga, Tokyo 1738605, Japan; 4.Komatsu Ltd, Minato Ku, 2-3-6 Akasaka, Tokyo 1078414, Japan; 5.Tech Univ Muinch, Inst Neurosci, Arcisstr 21, D-80333 Munich, Germany; 6.Edogawabashi Clin, Bunkyo Ku, 1-19-6 Sekiguchi, Tokyo 1120014, Japan |
推荐引用方式 GB/T 7714 | Shiramatsu, Tomoyo Isoguchi,Takahashi, Kazusa,Noda, Takahiro,et al. MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT[J],2016,332:38-52. |
APA | Shiramatsu, Tomoyo Isoguchi,Takahashi, Kazusa,Noda, Takahiro,Kanzaki, Ryohei,Nakahara, Haruka,&Takahashi, Hirokazu.(2016).MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT.NEUROSCIENCE,332,38-52. |
MLA | Shiramatsu, Tomoyo Isoguchi,et al."MICROELECTRODE MAPPING OF TONOTOPIC, LAMINAR, AND FIELD-SPECIFIC ORGANIZATION OF THALAMO-CORTICAL PATHWAY IN RAT".NEUROSCIENCE 332(2016):38-52. |
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