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In the Asian monsoon margin of northwest China, millennial-scale precipitation and effective moisture changes during the Holocene differ from those observed in the primary monsoon area. Whether these differences were caused by a change in precipitation or other hydroclimate factors remains controversial. We selected Huahai Lake, located in the western portion of the Hexi Corridor, at the northwest margin of the Asian monsoon area, to address this question. Using paleoclimate proxies (mineralogical assemblages and immobile elements) and results from a previous study, we inferred hydroclimate changes in this area during the early and middle Holocene (10.5-5.5 cal ka BP). Heavy precipitation and abundant runoff occurred during the early Holocene (10.5-8.8 cal ka BP). Proxies (carbonate content, total organic carbon and C/N) for precipitation minus evaporation (P -E) in the same section, however, revealed low P -E during the early Holocene and highest P -E in the middle Holocene (8.8-5.5 cal ka BP). Therefore, on a millennial timescale, precipitation amount and effective moisture changes were asynchronous during the early and middle Holocene. The precipitation and effective moisture pattern in the study area during that time span was different from patterns in both the Asian monsoon and westerly wind-influenced areas, suggesting an interplay between the two climate features. High precipitation during the early Holocene corresponded to a strengthened Asian monsoon. Highest P -E in the study area occurred during the middle Holocene and may have been caused by low evaporation, rather than high precipitation.