Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1038/jes.2015.18 |
Chlorine isotopic composition of perchlorate in human urine as a means of distinguishing among exposure sources | |
Poghosyan, Armen1; Morel-Espinosa, Maria2; Valentin-Blasini, Liza2; Blount, Benjamin C.2; Ferreccio, Catterina3; Steinmaus, Craig M.4; Sturchio, Neil C.1,5 | |
通讯作者 | Poghosyan, Armen |
来源期刊 | JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
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ISSN | 1559-0631 |
EISSN | 1559-064X |
出版年 | 2016 |
卷号 | 26期号:3页码:324-328 |
英文摘要 | Perchlorate (ClO4-) is a ubiquitous environmental contaminant with high human exposure potential. Natural perchlorate forms in the atmosphere from where it deposits onto the surface of Earth, whereas synthetic perchlorate is manufactured as an oxidant for industrial, aerospace, and military applications. Perchlorate exposure can potentially cause adverse health effects in humans by interfering with the production of thyroid hormones through competitively blocking iodide uptake. To control and reduce perchlorate exposure, the contributions of different sources of perchlorate exposure need to be quantified. Thus, we demonstrate a novel approach for determining the contribution of different perchlorate exposure sources by quantifying stable and radioactive chlorine isotopes of perchlorate extracted from composite urine samples from two distinct populations: one in Atlanta, USA and one in Taltal, Chile (Atacama region). Urinary perchlorate from the Atlanta region resembles indigenous natural perchlorate from the western USA (delta Cl-37 = +4.1 +/- 1.0%; Cl-36/Cl = 1 811 (+/- 136) x 10(-15)), and urinary perchlorate from the Taltal, Chile region is similar to natural perchlorate in nitrate salt deposits from the Atacama Desert of northern Chile (delta Cl-37 = -11.0 +/- 1.0%; Cl-36/Cl = 254 (+/- 40) x 10(-15)). Neither urinary perchlorate resembled the isotopic pattern found in synthetic perchlorate. These results indicate that natural perchlorate of regional provenance is the dominant exposure source for the two sample populations, and that chlorine isotope ratios provide a robust tool for elucidating perchlorate exposure pathways. |
英文关键词 | perchlorate isotope urine chlorine |
类型 | Article |
语种 | 英语 |
国家 | USA ; Chile |
收录类别 | SCI-E |
WOS记录号 | WOS:000374376600013 |
WOS关键词 | UNITED-STATES ; NATURAL PERCHLORATE ; THYROID-HORMONE ; ATACAMA DESERT ; DIETARY-INTAKE ; BREAST-MILK ; NEW-MEXICO ; WATER ; GROUNDWATER ; NITRATE |
WOS类目 | Environmental Sciences ; Public, Environmental & Occupational Health ; Toxicology |
WOS研究方向 | Environmental Sciences & Ecology ; Public, Environmental & Occupational Health ; Toxicology |
来源机构 | University of California, Berkeley |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/194407 |
作者单位 | 1.Univ Illinois, Dept Earth & Environm Sci, 845 West Taylor St,MC 186, Chicago, IL 60607 USA; 2.Ctr Dis Control & Prevent, Div Sci Lab, Natl Ctr Environm Hlth, Atlanta, GA USA; 3.Pontificia Univ Catolica Chile, Ctr FONDAP ACCDIS, Alameda 340, Santiago, Chile; 4.Univ Calif Berkeley, Sch Publ Hlth, Arsen Hlth Effects Res Program, Berkeley, CA 94720 USA; 5.Univ Delaware, Dept Geol Sci, Newark, DE 19716 USA |
推荐引用方式 GB/T 7714 | Poghosyan, Armen,Morel-Espinosa, Maria,Valentin-Blasini, Liza,et al. Chlorine isotopic composition of perchlorate in human urine as a means of distinguishing among exposure sources[J]. University of California, Berkeley,2016,26(3):324-328. |
APA | Poghosyan, Armen.,Morel-Espinosa, Maria.,Valentin-Blasini, Liza.,Blount, Benjamin C..,Ferreccio, Catterina.,...&Sturchio, Neil C..(2016).Chlorine isotopic composition of perchlorate in human urine as a means of distinguishing among exposure sources.JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY,26(3),324-328. |
MLA | Poghosyan, Armen,et al."Chlorine isotopic composition of perchlorate in human urine as a means of distinguishing among exposure sources".JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY 26.3(2016):324-328. |
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