Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1016/j.jes.2015.12.015 |
Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents | |
Wang, Bin1; Li, Ning2; Deng, Furong3; Buglak, Nicholas2; Park, George2; Su, Shu4; Ren, Aiguo1; Shen, Guofeng5; Tao, Shu4; Guo, Xinbiao3 | |
通讯作者 | Li, Ning ; Deng, Furong |
来源期刊 | JOURNAL OF ENVIRONMENTAL SCIENCES |
ISSN | 1001-0742 |
EISSN | 1878-7320 |
出版年 | 2016 |
卷号 | 47页码:201-210 |
英文摘要 | Epidemiological studies have demonstrated the exacerbation of respiratory diseases following sandstorm-derived particulate matter (PM) exposure. The presence of anthropogenic and biological agents on the sandstorm PM and the escalation of PM < 2.5 mu m (PM2.5) pollution in China have led to serious concerns regarding the health effects of PM2.5 during Asian sandstorms. We investigated how changes in PM2.5 composition, as the weather transitioned towards a sandstorm, affected human airway epithelial cells. Six PM2.5 samples covering two sandstorm events and their respective background and transition periods were collected in Baotou, an industrial city near the Gobi Desert in China. PM samples from all three periods had mild cytotoxicity in human bronchial epithelial cell line BEAS-2B, which was positively correlated with the contents of polycyclic aromatic hydrocarbons and several metals. All PM samples potently increased the release of interleukin-6 (IL-6) and interleukin-8 (IL-8). Endotoxin in all samples contributed significantly to the IL-6 response, with only a minor effect on IL-8. Cr was positively correlated with both IL-6 and IL-8 release, while Si was only associated with the increase of IL-6. Our study suggests that local agricultural and industrial surroundings in addition to the sandstorm play important roles in the respiratory effects of sandstorm-derived PM. (C) 2016 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V. |
英文关键词 | Sandstorm particles Human bronchial epithelial cells Particle constituents Inflammation Local environmental surroundings |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China ; USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000383932200022 |
WOS关键词 | ASIAN SAND DUST ; POLYCYCLIC AROMATIC-HYDROCARBONS ; DIESEL EXHAUST PARTICLES ; MURINE LUNG EOSINOPHILIA ; NATURAL RELOCATION HVNR ; LOS-ANGELES BASIN ; AIR-POLLUTION ; ALLERGIC RHINITIS ; OXIDATIVE STRESS ; DESERT DUST |
WOS类目 | Environmental Sciences |
WOS研究方向 | Environmental Sciences & Ecology |
来源机构 | 北京大学 |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/194378 |
作者单位 | 1.Peking Univ, Sch Publ Hlth, Minist Hlth Key Lab Reprod Hlth, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China; 2.Michigan State Univ, Coll Vet Med, Dept Pathobiol & Diagnost Invest, E Lansing, MI 48824 USA; 3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100191, Peoples R China; 4.Peking Univ, Coll Urban & Environm Sci, Lab Earth Surface Proc, Beijing 100871, Peoples R China; 5.Jiangsu Prov Acad Environm Sci, Nanjing 210036, Jiangsu, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Bin,Li, Ning,Deng, Furong,et al. Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents[J]. 北京大学,2016,47:201-210. |
APA | Wang, Bin.,Li, Ning.,Deng, Furong.,Buglak, Nicholas.,Park, George.,...&Guo, Xinbiao.(2016).Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents.JOURNAL OF ENVIRONMENTAL SCIENCES,47,201-210. |
MLA | Wang, Bin,et al."Human bronchial epithelial cell injuries induced by fine particulate matter from sandstorm and non-sandstorm periods: Association with particle constituents".JOURNAL OF ENVIRONMENTAL SCIENCES 47(2016):201-210. |
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