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DOI | 10.1016/j.chroma.2016.02.003 |
Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk | |
Wang, Yuan1; Li, Shaohui1; Zhang, Feifang1; Lu, Yifeng1; Yang, Bingcheng1; Zhang, Feng2; Liang, Xinmiao1 | |
通讯作者 | Zhang, Feifang ; Zhang, Feng |
来源期刊 | JOURNAL OF CHROMATOGRAPHY A
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ISSN | 0021-9673 |
EISSN | 1873-3778 |
出版年 | 2016 |
卷号 | 1437页码:8-14 |
英文摘要 | Matrix effect (ME) is always a major issue for the development of LC-MS/MS method. ME resulting from co-eluting residual matrix components can affect the ionization efficiency of target analytes, leading to quantification errors of the analytes of interest. The present work evaluates MEs of milk samples on simultaneous analysis of four aminoglycosides residues via LC-ESI/MS/MS including streptomycin, dihydrostreptomycin, spectinomycin and kanamycin. Approaches to reduce MEs were examined: optimization of the sample preparation, sample dilution and lower flow rate used. Three commercial sorbents were tested including Oasis MCX, Oasis HLB and Oasis WCX. WCX behaved better for all analytes, but high MEs (80.8-134.9%) were obtained. Therefore, a consecutive SPE of tC18-WCX was found to effectively reduce ME. Milk samples from different manufacturers were analyzed and low MEs (85.6-112.9%) were obtained. (C) 2016 Elsevier B.V. All rights reserved. |
英文关键词 | Matrix effect Aminoglycosides Sample preparation Consecutive SPE Milk LC-MS/MS |
类型 | Article |
语种 | 英语 |
国家 | Peoples R China |
收录类别 | SCI-E |
WOS记录号 | WOS:000371556700002 |
WOS关键词 | SOLID-PHASE EXTRACTION ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; AQUEOUS ENVIRONMENTAL-SAMPLES ; BOVINE-MILK ; WATER ; HONEY ; DIHYDROSTREPTOMYCIN ; STREPTOMYCIN ; ANTIBIOTICS ; SENSITIVITY |
WOS类目 | Biochemical Research Methods ; Chemistry, Analytical |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/194279 |
作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, 267 BO,130 Meilong RD, Shanghai 200237, Peoples R China; 2.Chinese Acad Inspect & Quarantine, Inst Food Safety, Beijing 100123, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Yuan,Li, Shaohui,Zhang, Feifang,et al. Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk[J],2016,1437:8-14. |
APA | Wang, Yuan.,Li, Shaohui.,Zhang, Feifang.,Lu, Yifeng.,Yang, Bingcheng.,...&Liang, Xinmiao.(2016).Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk.JOURNAL OF CHROMATOGRAPHY A,1437,8-14. |
MLA | Wang, Yuan,et al."Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk".JOURNAL OF CHROMATOGRAPHY A 1437(2016):8-14. |
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