Arid
DOI10.1016/j.chroma.2016.02.003
Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk
Wang, Yuan1; Li, Shaohui1; Zhang, Feifang1; Lu, Yifeng1; Yang, Bingcheng1; Zhang, Feng2; Liang, Xinmiao1
通讯作者Zhang, Feifang ; Zhang, Feng
来源期刊JOURNAL OF CHROMATOGRAPHY A
ISSN0021-9673
EISSN1873-3778
出版年2016
卷号1437页码:8-14
英文摘要

Matrix effect (ME) is always a major issue for the development of LC-MS/MS method. ME resulting from co-eluting residual matrix components can affect the ionization efficiency of target analytes, leading to quantification errors of the analytes of interest. The present work evaluates MEs of milk samples on simultaneous analysis of four aminoglycosides residues via LC-ESI/MS/MS including streptomycin, dihydrostreptomycin, spectinomycin and kanamycin. Approaches to reduce MEs were examined: optimization of the sample preparation, sample dilution and lower flow rate used. Three commercial sorbents were tested including Oasis MCX, Oasis HLB and Oasis WCX. WCX behaved better for all analytes, but high MEs (80.8-134.9%) were obtained. Therefore, a consecutive SPE of tC18-WCX was found to effectively reduce ME. Milk samples from different manufacturers were analyzed and low MEs (85.6-112.9%) were obtained. (C) 2016 Elsevier B.V. All rights reserved.


英文关键词Matrix effect Aminoglycosides Sample preparation Consecutive SPE Milk LC-MS/MS
类型Article
语种英语
国家Peoples R China
收录类别SCI-E
WOS记录号WOS:000371556700002
WOS关键词SOLID-PHASE EXTRACTION ; HYDROPHILIC INTERACTION CHROMATOGRAPHY ; AQUEOUS ENVIRONMENTAL-SAMPLES ; BOVINE-MILK ; WATER ; HONEY ; DIHYDROSTREPTOMYCIN ; STREPTOMYCIN ; ANTIBIOTICS ; SENSITIVITY
WOS类目Biochemical Research Methods ; Chemistry, Analytical
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
资源类型期刊论文
条目标识符http://119.78.100.177/qdio/handle/2XILL650/194279
作者单位1.E China Univ Sci & Technol, Sch Pharm, 267 BO,130 Meilong RD, Shanghai 200237, Peoples R China;
2.Chinese Acad Inspect & Quarantine, Inst Food Safety, Beijing 100123, Peoples R China
推荐引用方式
GB/T 7714
Wang, Yuan,Li, Shaohui,Zhang, Feifang,et al. Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk[J],2016,1437:8-14.
APA Wang, Yuan.,Li, Shaohui.,Zhang, Feifang.,Lu, Yifeng.,Yang, Bingcheng.,...&Liang, Xinmiao.(2016).Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk.JOURNAL OF CHROMATOGRAPHY A,1437,8-14.
MLA Wang, Yuan,et al."Study of matrix effects for liquid chromatography-electrospray ionization tandem mass spectrometric analysis of 4 aminoglycosides residues in milk".JOURNAL OF CHROMATOGRAPHY A 1437(2016):8-14.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yuan]的文章
[Li, Shaohui]的文章
[Zhang, Feifang]的文章
百度学术
百度学术中相似的文章
[Wang, Yuan]的文章
[Li, Shaohui]的文章
[Zhang, Feifang]的文章
必应学术
必应学术中相似的文章
[Wang, Yuan]的文章
[Li, Shaohui]的文章
[Zhang, Feifang]的文章
相关权益政策
暂无数据
收藏/分享

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。