Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1128/IAI.01066-15 |
Card9-and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection | |
Hung, Chiung-Yu1; Castro-Lopez, Natalia; Cole, Garry T. | |
通讯作者 | Hung, Chiung-Yu |
来源期刊 | INFECTION AND IMMUNITY |
ISSN | 0019-9567 |
EISSN | 1098-5522 |
出版年 | 2016 |
卷号 | 84期号:4页码:1166-1175 |
英文摘要 | Coccidioidomycosis is a potentially life-threatening respiratory disease which is endemic to the southwestern United States and arid regions of Central and South America. It is responsible for approximately 150,000 infections annually in the United States alone. Almost every human organ has been reported to harbor parasitic cells of Coccidioides spp. in collective cases of the disseminated form of this mycosis. Current understanding of the mechanisms of protective immunity against lung infection has been largely derived from murine models of pulmonary coccidioidomycosis. However, little is known about the nature of the host response to Coccidioides in extrapulmonary tissue. Primary subcutaneous coccidioidal infection is rare but has been reported to result in disseminated disease. Here, we show that activation of MyD88 and Card9 signal pathways are required for resistance to Coccidioides infection following subcutaneous challenge of C57BL/6 mice, which correlates with earlier findings of the protective response to pulmonary infection. MyD88(-)/(-) and Card9(-)/(-) mice recruited reduced numbers of T cells, B cells, and neutrophils to the Coccidioides-infected hypodermis compared to wild-type mice; however, neutrophils were dispensable for resistance to skin infection. Further studies have shown that gamma interferon (IFN-gamma) production and activation of Th1 cells characterize resistance to subcutaneous infection. Furthermore, activation of a phagosomal enzyme, inducible nitric oxide synthase, which is necessary for NO production, is a requisite for fungal clearance in the hypodermis. Collectively, our data demonstrate that MyD88- and Card9-mediated IFN-gamma and nitric oxide production is essential for protection against subcutaneous Coccidioides infection. |
类型 | Article |
语种 | 英语 |
国家 | USA |
收录类别 | SCI-E |
WOS记录号 | WOS:000377103600028 |
WOS关键词 | PRIMARY CUTANEOUS COCCIDIOIDOMYCOSIS ; VACCINE IMMUNITY ; REACTIVE OXYGEN ; INNATE IMMUNITY ; ANIMAL-MODELS ; NADPH OXIDASE ; HOST-DEFENSE ; TH17 CELLS ; RECEPTOR ; MICE |
WOS类目 | Immunology ; Infectious Diseases |
WOS研究方向 | Immunology ; Infectious Diseases |
来源机构 | Arizona State University |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/193602 |
作者单位 | 1.Univ Texas San Antonio, Dept Biol, San Antonio, TX USA; 2.Univ Texas San Antonio, South Texas Ctr Emerging Infect Dis, San Antonio, TX USA |
推荐引用方式 GB/T 7714 | Hung, Chiung-Yu,Castro-Lopez, Natalia,Cole, Garry T.. Card9-and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection[J]. Arizona State University,2016,84(4):1166-1175. |
APA | Hung, Chiung-Yu,Castro-Lopez, Natalia,&Cole, Garry T..(2016).Card9-and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection.INFECTION AND IMMUNITY,84(4),1166-1175. |
MLA | Hung, Chiung-Yu,et al."Card9-and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection".INFECTION AND IMMUNITY 84.4(2016):1166-1175. |
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