Knowledge Resource Center for Ecological Environment in Arid Area
DOI | 10.1017/S0950268815002010 |
High burden of invasive group A streptococcal disease in the Northern Territory of Australia | |
Boyd, R.1; Patel, M.2; Currie, B. J.3,4; Holt, D. C.4; Harris, T.4; Krause, V.1 | |
通讯作者 | Boyd, R. |
来源期刊 | EPIDEMIOLOGY AND INFECTION |
ISSN | 0950-2688 |
EISSN | 1469-4409 |
出版年 | 2016 |
卷号 | 144期号:5页码:1018-1027 |
英文摘要 | Although the incidence of invasive group A streptococcal disease in northern Australia is very high, little is known of the regional epidemiology and molecular characteristics. We conducted a case series of Northern Territory residents reported between 2011 and 2013 with Streptococcus pyogenes isolates from a normally sterile site. Of the 128 reported episodes, the incidence was disproportionately high in the Indigenous population at 69.7/100 000 compared to 8.8/100 000 in the non-Indigenous population. Novel to the Northern Territory is the extremely high incidence in haemodialysis patients of 2205.9/100 000 population; and for whom targeted infection control measures could prevent transmission. The incidences in the tropical north and semi-arid Central Australian regions were similar. Case fatality was 8% (10/128) and streptococcal toxic shock syndrome occurred in 14 (11%) episodes. Molecular typing of 82 isolates identified 28 emm types, of which 63 (77%) were represented by four emm clusters. Typing confirmed transmission between infant twins. While the diverse range of emm types presents a challenge for effective coverage by vaccine formulations, the limited number of emm clusters raises optimism should cluster-specific cross-protection prove efficacious. Further studies are required to determine effectiveness of chemoprophylaxis for contacts and to inform public health response. |
英文关键词 | Infectious disease epidemiology public health emerging infections streptococcal infections Streptococcus pyogenes vaccines |
类型 | Article |
语种 | 英语 |
国家 | Australia |
收录类别 | SCI-E |
WOS记录号 | WOS:000371720700014 |
WOS关键词 | ACUTE RHEUMATIC-FEVER ; VACCINE DEVELOPMENT ; ABORIGINAL COMMUNITIES ; INDIGENOUS COMMUNITIES ; INFECTION ; EPIDEMIOLOGY ; CHILDREN ; QUEENSLAND ; PYOGENES ; SKIN |
WOS类目 | Public, Environmental & Occupational Health ; Infectious Diseases |
WOS研究方向 | Public, Environmental & Occupational Health ; Infectious Diseases |
资源类型 | 期刊论文 |
条目标识符 | http://119.78.100.177/qdio/handle/2XILL650/192848 |
作者单位 | 1.Ctr Dis Control, Tiwi, NT, Australia; 2.Australian Natl Univ, Natl Ctr Epidemiol & Populat Hlth, Canberra, ACT, Australia; 3.Royal Darwin Hosp, Tiwi, NT 0810, Australia; 4.Charles Darwin Univ, Menzies Sch Hlth Res, Div Global & Trop Hlth, Casuarina, NT, Australia |
推荐引用方式 GB/T 7714 | Boyd, R.,Patel, M.,Currie, B. J.,et al. High burden of invasive group A streptococcal disease in the Northern Territory of Australia[J],2016,144(5):1018-1027. |
APA | Boyd, R.,Patel, M.,Currie, B. J.,Holt, D. C.,Harris, T.,&Krause, V..(2016).High burden of invasive group A streptococcal disease in the Northern Territory of Australia.EPIDEMIOLOGY AND INFECTION,144(5),1018-1027. |
MLA | Boyd, R.,et al."High burden of invasive group A streptococcal disease in the Northern Territory of Australia".EPIDEMIOLOGY AND INFECTION 144.5(2016):1018-1027. |
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